ENSG00000104290


Homo sapiens

Features
Gene ID: ENSG00000104290
  
Biological name :FZD3
  
Synonyms : frizzled class receptor 3 / FZD3 / Q9NPG1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p21.1
Gene start: 28494205
Gene end: 28574268
  
Corresponding Affymetrix probe sets: 219683_at (Human Genome U133 Plus 2.0 Array)   227499_at (Human Genome U133 Plus 2.0 Array)   227524_at (Human Genome U133 Plus 2.0 Array)   239082_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000437489
Ensembl peptide - ENSP00000240093
Ensembl peptide - ENSP00000430125
NCBI entrez gene - 7976     See in Manteia.
OMIM - 606143
RefSeq - XM_017013841
RefSeq - NM_017412
RefSeq - NM_145866
RefSeq Peptide - NP_059108
RefSeq Peptide - NP_665873
swissprot - Q9NPG1
swissprot - E5RGI9
Ensembl - ENSG00000104290
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fzd3aENSDARG00000021664Danio rerio
 FZD3ENSGALG00000042308Gallus gallus
 Fzd3ENSMUSG00000007989Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FZD6 / O60353 / frizzled class receptor 6ENSG0000016493053
FZD1 / Q9UP38 / frizzled class receptor 1ENSG0000015724036
FZD7 / O75084 / frizzled class receptor 7ENSG0000015576035
FZD2 / Q14332 / frizzled class receptor 2ENSG0000018034035
FZD5 / Q13467 / frizzled class receptor 5ENSG0000016325132
FZD10 / Q9ULW2 / frizzled class receptor 10ENSG0000011143230
FZD8 / Q9H461 / frizzled class receptor 8ENSG0000017728330
FZD9 / O00144 / frizzled class receptor 9ENSG0000018876329
FZD4 / Q9ULV1 / frizzled class receptor 4ENSG0000017480426
SMO / Q99835 / smoothened, frizzled class receptorENSG0000012860223
SFRP4 / Q6FHJ7 / secreted frizzled related protein 4ENSG0000010648311
SFRP1 / Q8N474 / secreted frizzled related protein 1ENSG0000010433210
FRZB / Q92765 / frizzled related proteinENSG0000016299810
SFRP5 / Q5T4F7 / secreted frizzled related protein 5ENSG000001200579
SFRP2 / Q96HF1 / secreted frizzled related protein 2ENSG000001454239


Protein motifs (from Interpro)
Interpro ID Name
 IPR000539  Frizzled/Smoothened, transmembrane domain
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR017981  GPCR, family 2-like
 IPR020067  Frizzled domain
 IPR026553  Frizzled-3, vertebrates
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001736 establishment of planar polarity IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0002052 positive regulation of neuroblast proliferation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030182 neuron differentiation ISS
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0033278 cell proliferation in midbrain IEA
 biological_processGO:0035567 non-canonical Wnt signaling pathway IBA
 biological_processGO:0036342 post-anal tail morphogenesis IEA
 biological_processGO:0036514 dopaminergic neuron axon guidance IEA
 biological_processGO:0036515 serotonergic neuron axon guidance IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045976 negative regulation of mitotic cell cycle, embryonic IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IDA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway NAS
 biological_processGO:0061549 sympathetic ganglion development IEA
 biological_processGO:0071679 commissural neuron axon guidance IEA
 biological_processGO:1900118 negative regulation of execution phase of apoptosis IEA
 biological_processGO:1904693 midbrain morphogenesis TAS
 biological_processGO:1904938 planar cell polarity pathway involved in axon guidance IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0032433 filopodium tip IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0048786 presynaptic active zone IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017147 Wnt-protein binding NAS
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0042813 Wnt-activated receptor activity NAS


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)
Ca2+ pathway
PCP/CE pathway
Asymmetric localization of PCP proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000180900 SCRIB / Q14160 / scribbled planar cell polarity protein  / complex / reaction
 ENSG00000162738 Q9ULK5 / VANGL2 / VANGL planar cell polarity protein 2  / complex / reaction






 

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