ENSG00000110237


Homo sapiens
domainARHGEF17superfamilyregulationrhodblhomologydhwdproteinsignaltransductiongtpaseguanyl-nucleotideexchangefactoractivityph-likeyvtnrepeat-like-containing-repeat-containingg-proteincoupledreceptorsignalingpathwayactincytoskeletonorganizationapoptoticprocess

Features
Gene ID: ENSG00000110237
  
Biological name :ARHGEF17
  
Synonyms : ARHGEF17 / Q96PE2 / Rho guanine nucleotide exchange factor 17
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.4
Gene start: 73308289
Gene end: 73369388
  
Corresponding Affymetrix probe sets: 203756_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263674
Ensembl peptide - ENSP00000441135
Ensembl peptide - ENSP00000493940
NCBI entrez gene - 9828     See in Manteia.
OMIM - 617043
RefSeq - XM_017018624
RefSeq - NM_014786
RefSeq - XM_017018623
RefSeq Peptide - NP_055601
swissprot - Q96PE2
swissprot - H0YFZ8
Ensembl - ENSG00000110237
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARHGEF17ENSDARG00000101644Danio rerio
 ENSGALG00000017326Gallus gallus
 Q80U35ENSMUSG00000032875Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SPAG9 / O60271 / sperm associated antigen 9ENSG0000000829415
Q9UPT6 / MAPK8IP3 / mitogen-activated protein kinase 8 interacting protein 3ENSG0000013883415
Q9HCE6 / ARHGEF10L / Rho guanine nucleotide exchange factor 10 likeENSG0000007496413
O15013 / ARHGEF10 / Rho guanine nucleotide exchange factor 10ENSG0000010472812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR011993  PH-like domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
cell communicationcellular response to stimuluscellular component organizationactin filament-based processcell deathregulation of molecular functioncell communicationcellular response to stimuluscellular component organizationactin filament-based processcell deathregulation of molecular functioncell communicationcellular response to stimuluscellular component organizationactin filament-based processcell deathregulation of molecular functioncell communicationcellular response to stimuluscellular component organizationactin filament-based processcell deathregulation of molecular functioncell communicationcellular response to stimuluscellular component organizationactin filament-based processcell deathregulation of molecular functioncell communicationcellular response to stimuluscellular component organizationactin filament-based processcell deathregulation of molecular functioncell communicationcellular response to stimuluscellular component organizationactin filament-based processcell deathregulation of molecular functioncell communicationcellular response to stimuluscellular component organizationactin filament-based processcell deathregulation of molecular functioncell communicationcellular response to stimuluscellular component organizationactin filament-based processcell deathregulation of molecular functioncell communicationcellular response to stimuluscellular component organizationactin filament-based processcell deathregulation of molecular functioncell communicationcell communicationcellular response to stcellular response to stimuluscellular component orgacellular component organizationactin filament-based practin filament-based processcell deathcell deathregulation of molecularregulation of molecular function
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellcellcellcellcellcellcellcellcellcellcellcell
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0030036 actin cytoskeleton organization IDA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr