ENSG00000114374


Homo sapiens

Features
Gene ID: ENSG00000114374
  
Biological name :USP9Y
  
Synonyms : O00507 / ubiquitin specific peptidase 9, Y-linked / USP9Y
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: Y
Strand: 1
Band: q11.221
Gene start: 12701231
Gene end: 12860839
  
Corresponding Affymetrix probe sets: 206624_at (Human Genome U133 Plus 2.0 Array)   228492_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000342812
Ensembl peptide - ENSP00000406876
NCBI entrez gene - 8287     See in Manteia.
OMIM - 400005
RefSeq - XM_017030078
RefSeq - NM_004654
RefSeq Peptide - NP_004645
swissprot - O00507
swissprot - H7C2M9
Ensembl - ENSG00000114374
  
Related genetic diseases (OMIM): 415000 - Spermatogenic failure, Y-linked, 2, 415000
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Usp9yENSMUSG00000069044Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP9X / Q93008 / ubiquitin specific peptidase 9, X-linkedENSG0000012448692
USP24 / Q9UPU5 / ubiquitin specific peptidase 24ENSG0000016240231
USP34 / Q70CQ2 / ubiquitin specific peptidase 34ENSG0000011546420
USP47 / Q96K76 / ubiquitin specific peptidase 47ENSG000001702427
USP7 / Q93009 / ubiquitin specific peptidase 7ENSG000001875557
USP40 / Q9NVE5 / ubiquitin specific peptidase 40ENSG000000859826
USP48 / Q86UV5 / ubiquitin specific peptidase 48ENSG000000906866
USP41 / Q3LFD5 / ubiquitin specific peptidase 41ENSG000001611333
USP18 / Q9UMW8 / ubiquitin specific peptidase 18ENSG000001849793


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway ISS
 biological_processGO:0007283 spermatogenesis TAS
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0016579 protein deubiquitination ISS
 biological_processGO:0030509 BMP signaling pathway ISS
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity TAS
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0070410 co-SMAD binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000027 Azoospermia 
Show

 HP:0000028 Cryptorchidism "Absence of one or both testes from the scrotum owing to failure of the testis or testes to descend through the inguinal canal to the testis." [HPO:curators]
Show

 HP:0000798 Oligospermia 
Show

 HP:0001450 Y-linked inheritance "A mode of inheritance that is observed for traits related to a gene encoded on the Y chromosome." [HPO:curators]
Show

 HP:0003251 Male infertility 
Show

 HP:0008734 Decreased testicular size 
Show

 HP:0011961 Non-obstructive azoospermia "Absence of any measurable level of sperm in his semen, resulting from a defect in the production of spermatozoa in the testes. Can be differentiated from obstructive azoospermia on the basis of testicular biopsy." [HPO:probinson, pmid:20514278]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr