ENSG00000114771


Homo sapiens
activityAADAChydrolaseprocessmembranelipasealphabetadeacetylaseserinemetaboliccatabolictriglycerideendoplasmicreticulumorganellefold-arylacetamidefoldgdxgputativeactivesitexenobioticregulationintegralcomponentintracellularmembrane-boundedcatalyticcarboxylic

Features
Gene ID: ENSG00000114771
  
Biological name :AADAC
  
Synonyms : AADAC / arylacetamide deacetylase / P22760
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q25.1
Gene start: 151814037
Gene end: 151828488
  
Corresponding Affymetrix probe sets: 205969_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000232892
Ensembl peptide - ENSP00000419620
NCBI entrez gene - 13     See in Manteia.
OMIM - 600338
RefSeq - NM_001086
RefSeq - XM_005247104
RefSeq Peptide - NP_001077
swissprot - C9K0E9
swissprot - P22760
Ensembl - ENSG00000114771
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aadacENSDARG00000063621Danio rerio
 ENSGALG00000010364Gallus gallus
 AadacENSMUSG00000027761Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6P093 / AADACL2 / arylacetamide deacetylase like 2ENSG0000019795351
NCEH1 / Q6PIU2 / neutral cholesterol ester hydrolase 1ENSG0000014495943
Q5VUY2 / AADACL4 / arylacetamide deacetylase like 4ENSG0000020451831
Q5VUY0 / AADACL3 / arylacetamide deacetylase like 3ENSG0000018898430


Protein motifs (from Interpro)
Interpro ID Name
 IPR013094  Alpha/beta hydrolase fold-3
 IPR017157  Arylacetamide deacetylase
 IPR029058  Alpha/Beta hydrolase fold
 IPR033140  Lipase, GDXG, putative serine active site


Gene Ontology (GO)
response to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalcellular metabolic processcellular response to stimuluscatabolic processprimary metabolic processorganic substance metabolic processresponse to chemicalresponse to chemicalcellular metabolic proccellular metabolic processcellular response to stcellular response to stimuluscatabolic processcatabolic processprimary metabolic proceprimary metabolic processorganic substance metaborganic substance metabolic process
hydrolase activityhydrolase activityhydrolase activityhydrolase activityhydrolase activityhydrolase activityhydrolase activityhydrolase activityhydrolase activityhydrolase activityhydrolase activityhydrolase activity
cellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellcellorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009056 catabolic process IBA
 biological_processGO:0010898 positive regulation of triglyceride catabolic process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003824 catalytic activity TAS
 molecular_functionGO:0004806 triglyceride lipase activity IBA
 molecular_functionGO:0016298 lipase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017171 serine hydrolase activity IDA
 molecular_functionGO:0019213 deacetylase activity TAS
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Phase I - Functionalization of compounds


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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