ENSG00000115233


Homo sapiens

Features
Gene ID: ENSG00000115233
  
Biological name :PSMD14
  
Synonyms : O00487 / proteasome 26S subunit, non-ATPase 14 / PSMD14
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q24.2
Gene start: 161308038
Gene end: 161411717
  
Corresponding Affymetrix probe sets: 212296_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000386541
Ensembl peptide - ENSP00000399311
NCBI entrez gene - 10213     See in Manteia.
OMIM - 607173
RefSeq - NM_005805
RefSeq Peptide - NP_005796
swissprot - C9JW37
swissprot - A0A140VKF2
swissprot - O00487
Ensembl - ENSG00000115233
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmd14ENSDARG00000063100Danio rerio
 PSMD14ENSGALG00000011128Gallus gallus
 O35593ENSMUSG00000026914Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000555  JAB1/MPN/MOV34 metalloenzyme domain
 IPR024969  Rpn11/EIF3F, C-terminal
 IPR035299  26S Proteasome non-ATPase regulatory subunit 14
 IPR037518  MPN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0000724 double-strand break repair via homologous recombination IMP
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0006521 regulation of cellular amino acid metabolic process TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010950 positive regulation of endopeptidase activity IEA
 biological_processGO:0010972 negative regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0038061 NIK/NF-kappaB signaling TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0055085 transmembrane transport TAS
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS
 biological_processGO:0061136 regulation of proteasomal protein catabolic process IMP
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0070536 protein K63-linked deubiquitination TAS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway TAS
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway TAS
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation TAS
 cellular_componentGO:0000502 proteasome complex TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0008541 proteasome regulatory particle, lid subcomplex IMP
 cellular_componentGO:0022624 proteasome accessory complex ISS
 cellular_componentGO:0031597 cytosolic proteasome complex IEA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061133 endopeptidase activator activity IMP
 molecular_functionGO:0061578 Lys63-specific deubiquitinase activity TAS
 molecular_functionGO:0070628 proteasome binding IDA


Pathways (from Reactome)
Pathway description
Cross-presentation of soluble exogenous antigens (endosomes)
Defective CFTR causes cystic fibrosis
Degradation of beta-catenin by the destruction complex
Degradation of DVL
Degradation of AXIN
Degradation of GLI2 by the proteasome
Downstream TCR signaling
ER-Phagosome pathway
FCERI mediated NF-kB activation
G2/M Checkpoints
Hedgehog on state
Hedgehog ligand biogenesis
Interleukin-1 signaling
MAPK6/MAPK4 signaling
Metalloprotease DUBs
Neddylation
NIK-->noncanonical NF-kB signaling
Neutrophil degranulation
Negative regulation of NOTCH4 signaling
Regulation of expression of SLITs and ROBOs
SCF(Skp2)-mediated degradation of p27/p21
TNFR2 non-canonical NF-kB pathway
UCH proteinases
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Orc1 removal from chromatin
RUNX1 regulates transcription of genes involved in differentiation of HSCs
GLI3 is processed to GLI3R by the proteasome
Separation of Sister Chromatids
Vif-mediated degradation of APOBEC3G
Regulation of activated PAK-2p34 by proteasome mediated degradation
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Ubiquitin-dependent degradation of Cyclin D1
Dectin-1 mediated noncanonical NF-kB signaling
Ub-specific processing proteases
Regulation of RAS by GAPs
Regulation of RUNX3 expression and activity
Autodegradation of the E3 ubiquitin ligase COP1
The role of GTSE1 in G2/M progression after G2 checkpoint
Degradation of GLI1 by the proteasome
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
Regulation of ornithine decarboxylase (ODC)
Autodegradation of Cdh1 by Cdh1:APC/C
Antigen processing: Ubiquitination & Proteasome degradation
Regulation of PTEN stability and activity
Regulation of RUNX2 expression and activity
Hh mutants that dont undergo autocatalytic processing are degraded by ERAD
Vpu mediated degradation of CD4
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
CDK-mediated phosphorylation and removal of Cdc6
CDT1 association with the CDC6:ORC:origin complex
CLEC7A (Dectin-1) signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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