ENSG00000115607


Homo sapiens

Features
Gene ID: ENSG00000115607
  
Biological name :IL18RAP
  
Synonyms : IL18RAP / interleukin 18 receptor accessory protein / O95256
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q12.1
Gene start: 102418689
Gene end: 102452565
  
Corresponding Affymetrix probe sets: 207072_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000387201
Ensembl peptide - ENSP00000389815
Ensembl peptide - ENSP00000264260
NCBI entrez gene - 8807     See in Manteia.
OMIM - 604509
RefSeq - NM_003853
RefSeq - XM_011512087
RefSeq - XM_011512088
RefSeq Peptide - NP_003844
swissprot - C9JLE2
swissprot - O95256
Ensembl - ENSG00000115607
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL18RAPENSGALG00000016788Gallus gallus
 Q9Z2B1ENSMUSG00000026068Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NP60 / IL1RAPL2 / interleukin 1 receptor accessory protein like 2ENSG0000018910828
IL1RAP / Q9NPH3 / interleukin 1 receptor accessory proteinENSG0000019608325
Q9NZN1 / IL1RAPL1 / interleukin 1 receptor accessory protein like 1ENSG0000016930624
IL1R1 / P14778 / interleukin 1 receptor type 1ENSG0000011559421
IL1RL2 / Q9HB29 / interleukin 1 receptor like 2ENSG0000011559821
IL1RL1 / Q01638 / interleukin 1 receptor like 1ENSG0000011560221
IL18R1 / Q13478 / interleukin 18 receptor 1ENSG0000011560421
IL1R2 / P27930 / interleukin 1 receptor type 2ENSG0000011559012


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR015621  Interleukin-1 receptor family
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0032609 interferon-gamma production IEA
 biological_processGO:0032635 interleukin-6 production IEA
 biological_processGO:0035655 interleukin-18-mediated signaling pathway TAS
 biological_processGO:0035744 T-helper 1 cell cytokine production IEA
 biological_processGO:0042119 neutrophil activation IEA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:0071351 cellular response to interleukin-18 IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-18 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115604 IL18R1 / Q13478 / interleukin 18 receptor 1  / complex / reaction
 ENSG00000150782 IL18 / Q14116 / interleukin 18  / complex / reaction






 

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