ENSG00000122012


Homo sapiens
synapticvesiclemembraneSV2Cmajorfacilitatorsuperfamilytoxicitybotulinumtoxintypebontsugarproteintransporttransmembraneactivitydfpentapeptiderepeattransporter-likeconservedsitedomainsvmfsneurotransmitterchemicaltransmission

Features
Gene ID: ENSG00000122012
  
Biological name :SV2C
  
Synonyms : Q496J9 / SV2C / synaptic vesicle glycoprotein 2C
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q13.3
Gene start: 76083172
Gene end: 76353939
  
Corresponding Affymetrix probe sets: 1562372_at (Human Genome U133 Plus 2.0 Array)   216086_at (Human Genome U133 Plus 2.0 Array)   242530_at (Human Genome U133 Plus 2.0 Array)   243139_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423541
Ensembl peptide - ENSP00000316983
NCBI entrez gene - 22987     See in Manteia.
OMIM - 610291
RefSeq - XM_011543282
RefSeq - NM_001297716
RefSeq - NM_014979
RefSeq - XM_011543281
RefSeq Peptide - NP_055794
RefSeq Peptide - NP_001284645
swissprot - Q496J9
swissprot - B3KT41
Ensembl - ENSG00000122012
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sv2cENSDARG00000059997Danio rerio
 SV2CENSGALG00000014967Gallus gallus
 Sv2cENSMUSG00000051111Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SV2A / Q7L0J3 / synaptic vesicle glycoprotein 2AENSG0000015916464
SV2B / Q7L1I2 / synaptic vesicle glycoprotein 2BENSG0000018551858
SVOPL / Q8N434 / SVOP likeENSG0000015770317
SVOP / Q8N4V2 / SV2 related proteinENSG0000016611117


Protein motifs (from Interpro)
Interpro ID Name
 IPR001646  Pentapeptide repeat
 IPR005828  Major facilitator, sugar transporter-like
 IPR005829  Sugar transporter, conserved site
 IPR011701  Major facilitator superfamily
 IPR020846  Major facilitator superfamily domain
 IPR022308  Synaptic vesicle protein SV2
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
establishment of localizationcell communicationestablishment of localizationcell communicationestablishment of localizationcell communicationestablishment of localizationcell communicationestablishment of localizationcell communicationestablishment of localizationcell communicationestablishment of localizationcell communicationestablishment of localizationcell communicationestablishment of localizationcell communicationestablishment of localizationcell communicationestablishment of localizationestablishment of localizationcell communicationcell communication
protein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingprotein bindingtransmembrane transporter activitytransmembrane transporter activity
cellmembranesynapseorganellecell junctioncellmembranesynapseorganellecell junctioncellmembranesynapseorganellecell junctioncellmembranesynapseorganellecell junctioncellmembranesynapseorganellecell junctioncellmembranesynapseorganellecell junctioncellmembranesynapseorganellecell junctioncellmembranesynapseorganellecell junctioncellmembranesynapseorganellecell junctioncellmembranesynapseorganellecell junctioncellcellmembranemembranesynapsesynapseorganelleorganellecell junctioncell junction
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030672 synaptic vesicle membrane TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Toxicity of botulinum toxin type D (BoNT/D)
Toxicity of botulinum toxin type A (BoNT/A)
Toxicity of botulinum toxin type F (BoNT/F)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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