ENSG00000123892


Homo sapiens

Features
Gene ID: ENSG00000123892
  
Biological name :RAB38
  
Synonyms : P57729 / RAB38 / RAB38, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q14.2
Gene start: 88113242
Gene end: 88175467
  
Corresponding Affymetrix probe sets: 219412_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000243662
Ensembl peptide - ENSP00000435340
Ensembl peptide - ENSP00000433317
NCBI entrez gene - 23682     See in Manteia.
OMIM - 606281
RefSeq - NM_022337
RefSeq Peptide - NP_071732
swissprot - P57729
swissprot - H0YEA4
swissprot - H0YDB7
swissprot - A0A024R191
Ensembl - ENSG00000123892
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab38bENSDARG00000112889Danio rerio
 RAB38ENSGALG00000028018Gallus gallus
 Rab38ENSMUSG00000030559Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB32 / Q13637 / RAB32, member RAS oncogene familyENSG0000011850865
RAB29 / O14966 / RAB29, member RAS oncogene familyENSG0000011728049
RAB7A / P51149 / RAB7A, member RAS oncogene familyENSG0000007578532
RAB23 / Q9ULC3 / RAB23, member RAS oncogene familyENSG0000011221030
RAB7B / Q96AH8 / RAB7B, member RAS oncogene familyENSG0000027660030
RAB9B / Q9NP90 / RAB9B, member RAS oncogene familyENSG0000012357029
RAB9A / P51151 / RAB9A, member RAS oncogene familyENSG0000012359529


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030697  Ras-related protein Rab29/Rab38/Rab32


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006996 organelle organization IEA
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007264 small GTPase mediated signal transduction NAS
 biological_processGO:0015031 protein transport NAS
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0035646 endosome to melanosome transport IMP
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0060155 platelet dense granule organization IEA
 biological_processGO:0072657 protein localization to membrane IMP
 biological_processGO:0090383 phagosome acidification IMP
 biological_processGO:1903232 melanosome assembly IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0033162 melanosome membrane TAS
 cellular_componentGO:0042470 melanosome IDA
 cellular_componentGO:0044233 ER-mitochondrion membrane contact site IDA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0030742 GTP-dependent protein binding IPI
 molecular_functionGO:0035650 AP-1 adaptor complex binding IPI
 molecular_functionGO:0035651 AP-3 adaptor complex binding IPI
 molecular_functionGO:0036461 BLOC-2 complex binding IPI


Pathways (from Reactome)
Pathway description
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100099 HPS4 / Q9NQG7 / HPS4, biogenesis of lysosomal organelles complex 3 subunit 2  / reaction
 ENSG00000107521 HPS1 / Q92902 / HPS1, biogenesis of lysosomal organelles complex 3 subunit 1  / reaction
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / complex
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / complex
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / complex
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / complex






 

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