ENSG00000125510


Homo sapiens

Features
Gene ID: ENSG00000125510
  
Biological name :OPRL1
  
Synonyms : opioid related nociceptin receptor 1 / OPRL1 / P41146
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q13.33
Gene start: 64080173
Gene end: 64100643
  
Corresponding Affymetrix probe sets: 206563_s_at (Human Genome U133 Plus 2.0 Array)   206564_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000336843
Ensembl peptide - ENSP00000347848
Ensembl peptide - ENSP00000336764
NCBI entrez gene - 4987     See in Manteia.
OMIM - 602548
RefSeq - NM_001318855
RefSeq - NM_182647
RefSeq - XM_017027855
RefSeq - NM_000913
RefSeq - NM_001200019
RefSeq - NM_001318853
RefSeq - NM_001318854
RefSeq - XM_011528828
RefSeq - XM_011528830
RefSeq - XM_017027852
RefSeq - XM_017027853
RefSeq - XM_017027854
RefSeq Peptide - NP_001305782
RefSeq Peptide - NP_000904
RefSeq Peptide - NP_001186948
RefSeq Peptide - NP_872588
RefSeq Peptide - NP_001305783
RefSeq Peptide - NP_001305784
swissprot - P41146
Ensembl - ENSG00000125510
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 oprl1ENSDARG00000071209Danio rerio
 OPRL1ENSGALG00000027965Gallus gallus
 Oprl1ENSMUSG00000027584Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
OPRK1 / P41145 / opioid receptor kappa 1ENSG0000008255653
OPRD1 / P41143 / opioid receptor delta 1ENSG0000011632951
OPRM1 / P35372 / opioid receptor mu 1ENSG0000011203850
SSTR3 / P32745 / somatostatin receptor 3ENSG0000027819537
SSTR4 / P31391 / somatostatin receptor 4ENSG0000013267135
SSTR5 / P35346 / somatostatin receptor 5ENSG0000016200935
SSTR1 / P30872 / somatostatin receptor 1ENSG0000013987433
SSTR2 / P30874 / somatostatin receptor 2ENSG0000018061633
NPBWR1 / P48145 / neuropeptides B and W receptor 1ENSG0000018372932
NPBWR2 / P48146 / neuropeptides B and W receptor 2ENSG0000012552231
MCHR1 / Q99705 / melanin concentrating hormone receptor 1ENSG0000012828526
MCHR2 / Q969V1 / melanin concentrating hormone receptor 2ENSG0000015203424


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001418  Opioid receptor
 IPR001420  X opioid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IGI
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007600 sensory perception TAS
 biological_processGO:0007610 behavior IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0035810 positive regulation of urine volume IEA
 biological_processGO:0038003 opioid receptor signaling pathway IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling IEA
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 biological_processGO:0060454 positive regulation of gastric acid secretion IEA
 biological_processGO:0106072 negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:1901386 negative regulation of voltage-gated calcium channel activity IEA
 biological_processGO:1904058 positive regulation of sensory perception of pain IEA
 biological_processGO:1904059 regulation of locomotor rhythm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0001626 nociceptin receptor activity IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IMP
 molecular_functionGO:0004985 opioid receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0042923 neuropeptide binding IBA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000168081 PNOC / Q13519 / prepronociceptin  / complex / reaction






 

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