ENSG00000126709


Homo sapiens
interferonregulationsignalingmembraneIFI6proteinifiapoptoticpathwayalpha-inducible-likereleasecytochromecmitochondriaimmuneresponsecysteine-typeendopeptidaseactivityinvolvedprocessmitochondrialdepolarizationtypeextrinsicabsenceligandmitochondrionplasmaintegral

Features
Gene ID: ENSG00000126709
  
Biological name :IFI6
  
Synonyms : IFI6 / interferon alpha inducible protein 6 / P09912
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p35.3
Gene start: 27666061
Gene end: 27672218
  
Corresponding Affymetrix probe sets: 204415_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000342513
Ensembl peptide - ENSP00000354736
Ensembl peptide - ENSP00000355152
NCBI entrez gene - 2537     See in Manteia.
OMIM - 147572
RefSeq - NM_022872
RefSeq - NM_002038
RefSeq - NM_022873
RefSeq Peptide - NP_002029
RefSeq Peptide - NP_075010
RefSeq Peptide - NP_075011
swissprot - P09912
Ensembl - ENSG00000126709
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-188i13.10ENSDARG00000075151Danio rerio
 si:dkey-188i13.11ENSDARG00000092895Danio rerio
 si:dkey-188i13.6ENSDARG00000074217Danio rerio
 si:dkey-188i13.9ENSDARG00000074754Danio rerio
 zgc:152791ENSDARG00000039243Danio rerio
 IFI27L2ENSGALG00000021627Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9H2X8 / IFI27L2 / interferon alpha inducible protein 27 like 2ENSG0000011963234
Q96BM0 / IFI27L1 / interferon alpha inducible protein 27 like 1ENSG0000016594833
IFI27 / interferon alpha inducible protein 27ENSG0000016594931


Protein motifs (from Interpro)
Interpro ID Name
 IPR009311  Interferon alpha-inducible protein IFI6/IFI27-like


Gene Ontology (GO)
cell communicationcellular component organizationcellular response to stimuluscell deathimmune responsenitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processregulation of biological qualityresponse to stressresponse to chemicalcell communicationcellular component organizationcellular response to stimuluscell deathimmune responsenitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processregulation of biological qualityresponse to stressresponse to chemicalcell communicationcellular component organizationcellular response to stimuluscell deathimmune responsenitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processregulation of biological qualityresponse to stressresponse to chemicalcell communicationcellular component organizationcellular response to stimuluscell deathimmune responsenitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processregulation of biological qualityresponse to stressresponse to chemicalcell communicationcellular component organizationcellular response to stimuluscell deathimmune responsenitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processregulation of biological qualityresponse to stressresponse to chemicalcell communicationcellular component organizationcellular response to stimuluscell deathimmune responsenitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processregulation of biological qualityresponse to stressresponse to chemicalcell communicationcellular component organizationcellular response to stimuluscell deathimmune responsenitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processregulation of biological qualityresponse to stressresponse to chemicalcell communicationcellular component organizationcellular response to stimuluscell deathimmune responsenitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processregulation of biological qualityresponse to stressresponse to chemicalcell communicationcellular component organizationcellular response to stimuluscell deathimmune responsenitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processregulation of biological qualityresponse to stressresponse to chemicalcell communicationcellular component organizationcellular response to stimuluscell deathimmune responsenitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processregulation of biological qualityresponse to stressresponse to chemicalcell commucell communicationcellular ccellular component organizationcellular rcellular response to stimuluscell deathcell deathimmune resimmune responsenitrogen cnitrogen compound metabolic processcellular mcellular metabolic processprimary meprimary metabolic processregulationregulation of molecular functionorganic suorganic substance metabolic processregulationregulation of biological qualityresponse tresponse to stressresponse tresponse to chemical
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellcellorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0001836 release of cytochrome c from mitochondria IMP
 biological_processGO:0006955 immune response TAS
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0051902 negative regulation of mitochondrial depolarization IMP
 biological_processGO:0060337 type I interferon signaling pathway TAS
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interferon alpha/beta signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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