ENSG00000129473


Homo sapiens

Features
Gene ID: ENSG00000129473
  
Biological name :BCL2L2
  
Synonyms : BCL2L2 / BCL2 like 2 / Q92843
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q11.2
Gene start: 23298790
Gene end: 23311759
  
Corresponding Affymetrix probe sets: 1555140_a_at (Human Genome U133 Plus 2.0 Array)   209311_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451197
Ensembl peptide - ENSP00000451701
Ensembl peptide - ENSP00000452265
Ensembl peptide - ENSP00000250405
Ensembl peptide - ENSP00000451148
Ensembl peptide - ENSP00000451234
NCBI entrez gene - 599     See in Manteia.
OMIM - 601931
RefSeq - NM_001199839
RefSeq - NM_004050
RefSeq Peptide - NP_001186768
RefSeq Peptide - NP_004041
swissprot - Q92843
swissprot - G3V3B7
swissprot - G3V3G8
swissprot - G3V4B7
swissprot - G3V5A9
swissprot - H0YJC7
Ensembl - ENSG00000129473
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Bcl2l2ENSMUSG00000089682Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BCL2L1 / Q07817 / BCL2 like 1ENSG0000017155247
BCL2 / P10415 / BCL2, apoptosis regulatorENSG0000017179141
BAK1 / Q16611 / BCL2 antagonist/killer 1ENSG0000003011021


Protein motifs (from Interpro)
Interpro ID Name
 IPR002475  Bcl2-like
 IPR003093  Apoptosis regulator, Bcl-2 protein, BH4
 IPR013280  Apoptosis regulator, Bcl-W
 IPR020717  Apoptosis regulator, Bcl-2, BH1 motif, conserved site
 IPR020726  Apoptosis regulator, Bcl-2, BH2 motif, conserved site
 IPR020731  Apoptosis regulator, Bcl-2, BH4 motif, conserved site
 IPR026298  Blc2 family
 IPR036834  Blc2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007283 spermatogenesis TAS
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0060011 Sertoli cell proliferation IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097136 Bcl-2 family protein complex IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051400 BH domain binding IEA
 molecular_functionGO:0097718 disordered domain specific binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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