ENSG00000131910


Homo sapiens

Features
Gene ID: ENSG00000131910
  
Biological name :NR0B2
  
Synonyms : NR0B2 / nuclear receptor subfamily 0 group B member 2 / Q15466
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.11
Gene start: 26911489
Gene end: 26913966
  
Corresponding Affymetrix probe sets: 206410_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000254227
NCBI entrez gene - 8431     See in Manteia.
OMIM - 604630
RefSeq - NM_021969
RefSeq Peptide - NP_068804
swissprot - Q15466
Ensembl - ENSG00000131910
  
Related genetic diseases (OMIM): 601665 - Obesity, mild, early-onset, 601665

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr0b2aENSDARG00000044685Danio rerio
 nr0b2bENSDARG00000102756Danio rerio
 NR0B2ENSGALG00000000887Gallus gallus
 Nr0b2ENSMUSG00000037583Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NR0B1 / P51843 / nuclear receptor subfamily 0 group B member 1ENSG0000016929737


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001723  Nuclear hormone receptor
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0008203 cholesterol metabolic process TAS
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0042974 retinoic acid receptor binding IEA
 molecular_functionGO:0042975 peroxisome proliferator activated receptor binding IEA
 molecular_functionGO:0046965 retinoid X receptor binding IEA
 molecular_functionGO:0046966 thyroid hormone receptor binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0001513 Obesity "A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY)." [MeSH:D009765]
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 HP:0003812 Phenotypic variability 
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 HP:0010982 Polygenic inheritance "A type of multifactorial inheritance governed by the simultaneous action of many (more than three) gene loci." [HPO:probinson, ISBN:978-0192628961]
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 HP:0012340 Decreased resting energy expenditure "An reduction in the number of calories used per unit time." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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