ENSG00000132507


Homo sapiens
translationelongationproteinEIF5Abindingfactortranslationalnucleustransportregulationdomainhypusinemrnaexportendoplasmicreticulummembranea-likesh-likesuperfamilynucleicacid-bindingob-foldribosomallsitec-terminalframeshiftingnucleocytoplasmicapoptotic

Features
Gene ID: ENSG00000132507
  
Biological name :EIF5A
  
Synonyms : EIF5A / eukaryotic translation initiation factor 5A / P63241
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.1
Gene start: 7306999
Gene end: 7312463
  
Corresponding Affymetrix probe sets: 201122_x_at (Human Genome U133 Plus 2.0 Array)   201123_s_at (Human Genome U133 Plus 2.0 Array)   213753_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000461688
Ensembl peptide - ENSP00000459611
Ensembl peptide - ENSP00000460284
Ensembl peptide - ENSP00000336702
Ensembl peptide - ENSP00000336776
Ensembl peptide - ENSP00000390677
Ensembl peptide - ENSP00000396073
Ensembl peptide - ENSP00000458269
Ensembl peptide - ENSP00000459196
NCBI entrez gene - 1984     See in Manteia.
OMIM - 600187
RefSeq - XM_005256509
RefSeq - NM_001143760
RefSeq - NM_001143761
RefSeq - NM_001143762
RefSeq - NM_001970
RefSeq Peptide - NP_001137234
RefSeq Peptide - NP_001961
RefSeq Peptide - NP_001137233
RefSeq Peptide - NP_001137232
swissprot - I3L504
swissprot - I3L397
swissprot - P63241
Ensembl - ENSG00000132507
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif5aENSDARG00000017235Danio rerio
 Eif5aENSMUSG00000078812Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6IS14 / EIF5AL1 / eukaryotic translation initiation factor 5A-like 1ENSG0000025362682
EIF5A2 / Q9GZV4 / eukaryotic translation initiation factor 5A2ENSG0000016357768


Protein motifs (from Interpro)
Interpro ID Name
 IPR001884  Translation elongation factor IF5A-like
 IPR008991  Translation protein SH3-like domain superfamily
 IPR012340  Nucleic acid-binding, OB-fold
 IPR014722  Ribosomal protein L2, domain 2
 IPR019769  Translation elongation factor, IF5A, hypusine site
 IPR020189  Translation elongation factor, IF5A C-terminal


Gene Ontology (GO)
macromolecule localizationestablishment of localizationorganic substance metabolic processcellular localizationprotein-containing complex localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processcell deathcellular component organizationmacromolecule localizationestablishment of localizationorganic substance metabolic processcellular localizationprotein-containing complex localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processcell deathcellular component organizationmacromolecule localizationestablishment of localizationorganic substance metabolic processcellular localizationprotein-containing complex localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processcell deathcellular component organizationmacromolecule localizationestablishment of localizationorganic substance metabolic processcellular localizationprotein-containing complex localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processcell deathcellular component organizationmacromolecule localizationestablishment of localizationorganic substance metabolic processcellular localizationprotein-containing complex localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processcell deathcellular component organizationmacromolecule localizationestablishment of localizationorganic substance metabolic processcellular localizationprotein-containing complex localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processcell deathcellular component organizationmacromolecule localizationestablishment of localizationorganic substance metabolic processcellular localizationprotein-containing complex localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processcell deathcellular component organizationmacromolecule localizationestablishment of localizationorganic substance metabolic processcellular localizationprotein-containing complex localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processcell deathcellular component organizationmacromolecule localizationestablishment of localizationorganic substance metabolic processcellular localizationprotein-containing complex localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processcell deathcellular component organizationmacromolecule localizationestablishment of localizationorganic substance metabolic processcellular localizationprotein-containing complex localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processcell deathcellular component organizationmacromoleculmacromolecule localizationestablishmenestablishment of localizationorganic subsorganic substance metabolic processcellular loccellular localizationprotein-contprotein-containing complex localizationnitrogen comnitrogen compound metabolic processbiosyntheticbiosynthetic processcellular metcellular metabolic processprimary metaprimary metabolic processcell deathcell deathcellular comcellular component organization
organic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingprotein-containing complex bindingorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound bindingprotein bindingprotein bindingprotein-containing complex bindingprotein-containing complex binding
cellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellcellorganelleorganellemembranemembraneprotein-containing complexprotein-containing complexextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0006406 mRNA export from nucleus IMP
 biological_processGO:0006412 translation IEA
 biological_processGO:0006414 translational elongation IEA
 biological_processGO:0006452 translational frameshifting IEA
 biological_processGO:0006611 protein export from nucleus IMP
 biological_processGO:0006913 nucleocytoplasmic transport IMP
 biological_processGO:0006915 apoptotic process IDA
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0008612 peptidyl-lysine modification to peptidyl-hypusine TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0045901 positive regulation of translational elongation ISS
 biological_processGO:0045905 positive regulation of translational termination IEA
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005642 annulate lamellae IDA
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0003746 translation elongation factor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017070 U6 snRNA binding IDA
 molecular_functionGO:0043022 ribosome binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IPI


Pathways (from Reactome)
Pathway description
Hypusine synthesis from eIF5A-lysine


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000095059 DHPS / P49366 / deoxyhypusine synthase  / reaction
 ENSG00000129932 DOHH / Q9BU89 / deoxyhypusine hydroxylase  / reaction






 

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