ENSG00000132604


Homo sapiens

Features
Gene ID: ENSG00000132604
  
Biological name :TERF2
  
Synonyms : Q15554 / telomeric repeat binding factor 2 / TERF2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q22.1
Gene start: 69355561
Gene end: 69408571
  
Corresponding Affymetrix probe sets: 1555183_at (Human Genome U133 Plus 2.0 Array)   1555185_x_at (Human Genome U133 Plus 2.0 Array)   203611_at (Human Genome U133 Plus 2.0 Array)   229790_at (Human Genome U133 Plus 2.0 Array)   235872_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000476905
Ensembl peptide - ENSP00000463079
Ensembl peptide - ENSP00000475507
Ensembl peptide - ENSP00000254942
Ensembl peptide - ENSP00000454955
Ensembl peptide - ENSP00000456022
Ensembl peptide - ENSP00000456062
Ensembl peptide - ENSP00000457094
Ensembl peptide - ENSP00000462523
Ensembl peptide - ENSP00000462726
NCBI entrez gene - 7014     See in Manteia.
OMIM - 602027
RefSeq - XM_005256124
RefSeq - NM_005652
RefSeq - XM_005256121
RefSeq - XM_005256122
RefSeq - XM_005256123
RefSeq Peptide - NP_005643
swissprot - H3BR06
swissprot - Q15554
swissprot - U3KQ35
swissprot - V9GYM1
swissprot - H3BR37
swissprot - H3BTA7
swissprot - J3KSJ9
swissprot - J3KTN8
swissprot - J3KSZ6
Ensembl - ENSG00000132604
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 terfaENSDARG00000039302Danio rerio
 TERF2ENSGALG00000000657Gallus gallus
 Terf2ENSMUSG00000031921Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TERF1 / P54274 / telomeric repeat binding factor 1ENSG0000014760119


Protein motifs (from Interpro)
Interpro ID Name
 IPR001005  SANT/Myb domain
 IPR009057  Homeobox-like domain superfamily
 IPR013867  Telomere repeat-binding factor, dimerisation domain
 IPR017357  Telomeric repeat-binding factor 1/2
 IPR017930  Myb domain
 IPR030657  Telomeric repeat-binding factor 2
 IPR031902  Telomeric repeat-binding factor 2, Rap1-binding domain
 IPR036507  Telomere repeat-binding factor, dimerisation domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0006278 RNA-dependent DNA biosynthetic process IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0016233 telomere capping NAS
 biological_processGO:0031627 telomeric loop formation IDA
 biological_processGO:0031848 protection from non-homologous end joining at telomere IEA
 biological_processGO:0032204 regulation of telomere maintenance IMP
 biological_processGO:0032205 negative regulation of telomere maintenance IDA
 biological_processGO:0032208 negative regulation of telomere maintenance via recombination ISS
 biological_processGO:0032210 regulation of telomere maintenance via telomerase IMP
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase IMP
 biological_processGO:0032214 negative regulation of telomere maintenance via semi-conservative replication NAS
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IMP
 biological_processGO:0061820 telomeric D-loop disassembly IGI
 biological_processGO:0070198 protein localization to chromosome, telomeric region IMP
 biological_processGO:0090398 cellular senescence NAS
 biological_processGO:1903770 negative regulation of beta-galactosidase activity IDA
 biological_processGO:1903824 negative regulation of telomere single strand break repair NAS
 biological_processGO:1904354 negative regulation of telomere capping IMP
 biological_processGO:1904357 negative regulation of telomere maintenance via telomere lengthening IMP
 biological_processGO:1904430 negative regulation of t-circle formation TAS
 biological_processGO:1905778 negative regulation of exonuclease activity IDA
 biological_processGO:1905839 negative regulation of telomeric D-loop disassembly IDA
 biological_processGO:2000773 negative regulation of cellular senescence IMP
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0000783 nuclear telomere cap complex IDA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0030870 Mre11 complex IDA
 cellular_componentGO:0070187 shelterin complex TAS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003691 double-stranded telomeric DNA binding ISS
 molecular_functionGO:0003720 telomerase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0042162 telomeric DNA binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044877 protein-containing complex binding IPI
 molecular_functionGO:0098505 G-rich strand telomeric DNA binding IDA


Pathways (from Reactome)
Pathway description
Meiotic synapsis
Packaging Of Telomere Ends
DNA Damage/Telomere Stress Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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