ENSG00000133606


Homo sapiens

Features
Gene ID: ENSG00000133606
  
Biological name :MKRN1
  
Synonyms : makorin ring finger protein 1 / MKRN1 / Q9UHC7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q34
Gene start: 140453040
Gene end: 140479569
  
Corresponding Affymetrix probe sets: 201285_at (Human Genome U133 Plus 2.0 Array)   209845_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418588
Ensembl peptide - ENSP00000419894
Ensembl peptide - ENSP00000419843
Ensembl peptide - ENSP00000419695
Ensembl peptide - ENSP00000419259
Ensembl peptide - ENSP00000418864
Ensembl peptide - ENSP00000418620
Ensembl peptide - ENSP00000255977
Ensembl peptide - ENSP00000416369
Ensembl peptide - ENSP00000417346
Ensembl peptide - ENSP00000417640
Ensembl peptide - ENSP00000417863
Ensembl peptide - ENSP00000417907
NCBI entrez gene - 23608     See in Manteia.
OMIM - 607754
RefSeq - NM_001291663
RefSeq - NM_013446
RefSeq - NM_001145125
RefSeq - XM_011515996
RefSeq - XM_011515997
RefSeq - XM_011515998
RefSeq Peptide - NP_001278592
RefSeq Peptide - NP_038474
RefSeq Peptide - NP_001138597
swissprot - Q9UHC7
swissprot - H7C588
swissprot - C9JYI0
swissprot - C9J031
swissprot - C9IZP5
swissprot - C9IY57
swissprot - F8WAS8
swissprot - F8WBJ4
swissprot - F8WEY8
swissprot - H7C4H5
swissprot - C9JYX8
Ensembl - ENSG00000133606
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mkrn1ENSDARG00000041665Danio rerio
 MKRN1ENSGALG00000012852Gallus gallus
 Mkrn1ENSMUSG00000029922Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MKRN3 / Q13064 / makorin ring finger protein 3ENSG0000017945547
MKRN2 / Q9H000 / makorin ring finger protein 2ENSG0000007597538


Protein motifs (from Interpro)
Interpro ID Name
 IPR000571  Zinc finger, CCCH-type
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR031644  E3 ubiquitin-protein ligase makorin 1, C-terminal
 IPR036855  Zinc finger, CCCH-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043491 protein kinase B signaling TAS
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity TAS


Pathways (from Reactome)
Pathway description
AKT phosphorylates targets in the cytosol
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction






 

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