ENSG00000134627


Homo sapiens

Features
Gene ID: ENSG00000134627
  
Biological name :PIWIL4
  
Synonyms : PIWIL4 / piwi like RNA-mediated gene silencing 4 / Q7Z3Z4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q21
Gene start: 94543840
Gene end: 94621421
  
Corresponding Affymetrix probe sets: 230480_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000439710
Ensembl peptide - ENSP00000444575
Ensembl peptide - ENSP00000440499
Ensembl peptide - ENSP00000299001
Ensembl peptide - ENSP00000413838
NCBI entrez gene - 143689     See in Manteia.
OMIM - 610315
RefSeq - NM_152431
RefSeq Peptide - NP_689644
swissprot - Q7Z3Z4
swissprot - F5H116
swissprot - F5GX26
swissprot - A0A140VKG8
Ensembl - ENSG00000134627
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Piwil4ENSMUSG00000036912Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PIWIL1 / Q96J94 / piwi like RNA-mediated gene silencing 1ENSG0000012520750
PIWIL3 / Q7Z3Z3 / piwi like RNA-mediated gene silencing 3ENSG0000018457140
PIWIL2 / Q8TC59 / piwi like RNA-mediated gene silencing 2ENSG0000019718137
AGO1 / Q9UL18 / argonaute 1, RISC catalytic componentENSG0000009284721
AGO2 / Q9UKV8 / argonaute 2, RISC catalytic componentENSG0000012390820
AGO3 / Q9H9G7 / argonaute 3, RISC catalytic componentENSG0000012607020
AGO4 / Q9HCK5 / argonaute 4, RISC catalytic componentENSG0000013469820


Protein motifs (from Interpro)
Interpro ID Name
 IPR003100  PAZ domain
 IPR003165  Piwi domain
 IPR012337  Ribonuclease H-like superfamily
 IPR036085  PAZ domain superfamily
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0010529 negative regulation of transposition ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031047 gene silencing by RNA ISS
 biological_processGO:0034587 piRNA metabolic process ISS
 biological_processGO:0043046 DNA methylation involved in gamete generation ISS
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0043186 P granule ISS
 cellular_componentGO:0071547 piP-body ISS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0034584 piRNA binding ISS


Pathways (from Reactome)
Pathway description
PIWI-interacting RNA (piRNA) biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000156414 TDRD9 / Q8NDG6 / tudor domain containing 9  / complex
 ENSG00000182134 TDRKH / Q9Y2W6 / tudor and KH domain containing  / complex
 ENSG00000143194 MAEL / Q96JY0 / maelstrom spermatogenic transposon silencer  / complex
 ENSG00000162639 HENMT1 / Q5T8I9 / HEN methyltransferase 1  / reaction






 

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