ENSG00000134824


Homo sapiens
acidFADS2processfattymetabolicmembranedomaindesaturaseactivitycytochromeb-likehemesteroidbindingbiosyntheticalpha-linoleniclinoleicendoplasmicreticulumintegralcomponentmetabolismsuperfamilylipidunsaturatedoxidation-reductionplasmastearoyl-coa-desaturaselinoleoyl-coa

Features
Gene ID: ENSG00000134824
  
Biological name :FADS2
  
Synonyms : FADS2 / fatty acid desaturase 2 / O95864
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q12.2
Gene start: 61792980
Gene end: 61867354
  
Corresponding Affymetrix probe sets: 202218_s_at (Human Genome U133 Plus 2.0 Array)   243953_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430225
Ensembl peptide - ENSP00000431091
Ensembl peptide - ENSP00000458917
Ensembl peptide - ENSP00000443867
Ensembl peptide - ENSP00000437965
Ensembl peptide - ENSP00000257261
Ensembl peptide - ENSP00000278840
Ensembl peptide - ENSP00000428522
Ensembl peptide - ENSP00000429500
Ensembl peptide - ENSP00000429693
Ensembl peptide - ENSP00000430054
NCBI entrez gene - 9415     See in Manteia.
OMIM - 606149
RefSeq - NM_001281502
RefSeq - NM_004265
RefSeq - NM_001281501
RefSeq Peptide - NP_001268430
RefSeq Peptide - NP_001268431
RefSeq Peptide - NP_004256
swissprot - E5RHL3
swissprot - O95864
swissprot - E5RGZ5
swissprot - E5RGD8
swissprot - F5GZ92
swissprot - F5GZU2
swissprot - F5H622
Ensembl - ENSG00000134824
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fads2ENSDARG00000019532Danio rerio
 Fads2ENSMUSG00000024665Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FADS1 / O60427 / fatty acid desaturase 1ENSG0000014948561
FADS3 / Q9Y5Q0 / fatty acid desaturase 3ENSG0000022196861


Protein motifs (from Interpro)
Interpro ID Name
 IPR001199  Cytochrome b5-like heme/steroid binding domain
 IPR005804  Fatty acid desaturase domain
 IPR012171  Fatty acid desaturase
 IPR036400  Cytochrome b5-like heme/steroid binding domain superfamily


Gene Ontology (GO)
primary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcellular metabolic processsmall molecule metabolic processbiosynthetic processoxidation-reduction processprimary metabolic proceprimary metabolic processorganic substance metaborganic substance metabolic processcellular metabolic proccellular metabolic processsmall molecule metabolismall molecule metabolic processbiosynthetic processbiosynthetic processoxidation-reduction prooxidation-reduction process
oxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activity
cellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellcellorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006636 unsaturated fatty acid biosynthetic process TAS
 biological_processGO:0036109 alpha-linolenic acid metabolic process TAS
 biological_processGO:0043651 linoleic acid metabolic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004768 stearoyl-CoA 9-desaturase activity IEA
 molecular_functionGO:0016213 linoleoyl-CoA desaturase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Linoleic acid (LA) metabolism
alpha-linolenic acid (ALA) metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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