ENSG00000134987


Homo sapiens
wdWDR36domainrrnarepeatsmall-subunitprocessomesuperfamily-repeat-containingprocessingnucleusnucleolusbindingcytosolutpyvtnrepeat-like-containingconservedsiteanaphase-promotingcomplexsubunitretinahomeostasisvisualperceptionbiologicalprocessregulationaxonextension

Features
Gene ID: ENSG00000134987
  
Biological name :WDR36
  
Synonyms : Q8NI36 / WDR36 / WD repeat domain 36
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q22.1
Gene start: 111091716
Gene end: 111130502
  
Corresponding Affymetrix probe sets: 226180_at (Human Genome U133 Plus 2.0 Array)   238677_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423067
Ensembl peptide - ENSP00000479950
Ensembl peptide - ENSP00000424628
NCBI entrez gene - 134430     See in Manteia.
OMIM - 609669
RefSeq - NM_139281
RefSeq Peptide - NP_644810
swissprot - A0A0A0MTB8
swissprot - Q8NI36
Ensembl - ENSG00000134987
  
Related genetic diseases (OMIM): 609887 - Glaucoma 1, open angle, G, 609887
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wdr36ENSDARG00000004774Danio rerio
 WDR36ENSGALG00000000247Gallus gallus
 Wdr36ENSMUSG00000038299Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR007319  Small-subunit processome, Utp21
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR024977  Anaphase-promoting complex subunit 4, WD40 domain
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
regulation of biological qualitynitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processsystem processcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthregulation of biological qualitynitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processsystem processcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthregulation of biological qualitynitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processsystem processcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthregulation of biological qualitynitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processsystem processcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthregulation of biological qualitynitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processsystem processcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthregulation of biological qualitynitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processsystem processcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthregulation of biological qualitynitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processsystem processcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthregulation of biological qualitynitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processsystem processcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthregulation of biological qualitynitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processsystem processcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthregulation of biological qualitynitrogen compound metabolic processcellular component biogenesiscellular metabolic processprimary metabolic processorganic substance metabolic processsystem processcellular component organizationanatomical structure developmentcellular developmental processcell growthdevelopmental growthregulation regulation of biological qualitynitrogen conitrogen compound metabolic processcellular cocellular component biogenesiscellular mecellular metabolic processprimary metprimary metabolic processorganic suborganic substance metabolic processsystem procsystem processcellular cocellular component organizationanatomical anatomical structure developmentcellular decellular developmental processcell growthcell growthdevelopmentdevelopmental growth
organic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingprotein bindingorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound bindingprotein bindingprotein binding
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0001895 retina homeostasis IEA
 biological_processGO:0006364 rRNA processing IBA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0030516 regulation of axon extension IEA
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0050896 response to stimulus IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0032040 small-subunit processome IBA
 cellular_componentGO:0034388 Pwp2p-containing subcomplex of 90S preribosome IBA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
rRNA modification in the nucleus and cytosol
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
Abnormality of the eyesAbnormality of the eyesAbnormality of the eyesAbnormality of the eyesAbnormality of the eyesAbnormality of the eyesAbnormality of the eyesAbnormality of the eyesAbnormality of the eyesAbnormality of the eyesAbnormality of the eyesAbnormality of the eyes
IDPhenotypeDefinition Genetic BG
 HP:0012108 Primary open angle glaucoma "A type of glaucoma with optic nerve damage in an eye with evidence of significant obstruction of the functional trabecular meshwork by the peripheral iris would be classified as having primary angle closure." [HPO:probinson, pmid:11815354]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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