ENSG00000135074


Homo sapiens

Features
Gene ID: ENSG00000135074
  
Biological name :ADAM19
  
Synonyms : ADAM19 / ADAM metallopeptidase domain 19 / Q9H013
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q33.3
Gene start: 157395534
Gene end: 157575775
  
Corresponding Affymetrix probe sets: 209765_at (Human Genome U133 Plus 2.0 Array)   221128_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431027
Ensembl peptide - ENSP00000257527
Ensembl peptide - ENSP00000428376
Ensembl peptide - ENSP00000428654
NCBI entrez gene - 8728     See in Manteia.
OMIM - 603640
RefSeq - XM_017010009
RefSeq - NM_033274
RefSeq - XM_005266003
RefSeq - XM_011534682
RefSeq Peptide - NP_150377
swissprot - Q9H013
swissprot - H0YC66
swissprot - E5RIS2
Ensembl - ENSG00000135074
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adam19bENSDARG00000067545Danio rerio
 ADAM19ENSGALG00000003744Gallus gallus
 Adam19ENSMUSG00000011256Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADAM12 / O43184 / ADAM metallopeptidase domain 12ENSG0000014884844
ADAM33 / Q9BZ11 / ADAM metallopeptidase domain 33ENSG0000014945139
ADAM15 / Q13444 / ADAM metallopeptidase domain 15ENSG0000014353734
ADAM8 / P78325 / ADAM metallopeptidase domain 8ENSG0000015165132
ADAM22 / Q9P0K1 / ADAM metallopeptidase domain 22ENSG0000000827728
ADAM28 / Q9UKQ2 / ADAM metallopeptidase domain 28ENSG0000004298028
ADAM11 / O75078 / ADAM metallopeptidase domain 11ENSG0000007367026
ADAM23 / O75077 / ADAM metallopeptidase domain 23ENSG0000011494826
ADAM7 / Q9H2U9 / ADAM metallopeptidase domain 7ENSG0000006920623


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR013032  EGF-like, conserved site
 IPR018358  Disintegrin, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR033596  ADAM19 peptidase
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0030198 extracellular matrix organization TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Invadopodia formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000107957 Q5TCZ1 / SH3PXD2A / SH3 and PX domains 2A  / complex / reaction






 

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