ENSG00000138463


Homo sapiens

Features
Gene ID: ENSG00000138463
  
Biological name :DIRC2
  
Synonyms : DIRC2 / disrupted in renal carcinoma 2 / Q96SL1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q21.1
Gene start: 122794795
Gene end: 122881139
  
Corresponding Affymetrix probe sets: 226026_at (Human Genome U133 Plus 2.0 Array)   229213_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000261038
Ensembl peptide - ENSP00000418554
NCBI entrez gene - 84925     See in Manteia.
OMIM - 602773
RefSeq - NM_032839
RefSeq Peptide - NP_116228
swissprot - Q05BS2
swissprot - Q96SL1
Ensembl - ENSG00000138463
  
Related genetic diseases (OMIM): 144700 - Renal cell carcinoma, 144700
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dirc2ENSDARG00000009783Danio rerio
 DIRC2ENSGALG00000032632Gallus gallus
 Dirc2ENSMUSG00000022848Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FLVCR1 / Q9Y5Y0 / feline leukemia virus subgroup C cellular receptor 1ENSG0000016276925
FLVCR2 / Q9UPI3 / feline leukemia virus subgroup C cellular receptor family member 2ENSG0000011968623
Q6UXD7 / SLC49A3 / solute carrier family 49 member 3ENSG0000016902623


Protein motifs (from Interpro)
Interpro ID Name
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0003745 Sporadic 
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 HP:0005584 Renal cell carcinoma "Renal cell carcinoma (also known as hypernephroma) is the most common form of kidney cancer arising from the proximal renal tubule. The tissue of origin for renal cell carcinoma is the proximal renal tubular epithelium. Renal cell carcinoma can be classified as 1) clear cell carcinoma, 2) papillary carcinoma, 3) chromophobe renal carcinoma, and 4) collecting duct carcinoma." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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