ENSG00000140379


Homo sapiens
apoptoticBCL2A1proteinprocessbcl-regulationactivity-likeapoptosisregulatorbhmotifconservedsiteblcmitochondrialsignalingpathwaybcl-relatedfamilysuperfamilyreleasecytochromecmitochondriafusionintrinsicresponsednadamage

Features
Gene ID: ENSG00000140379
  
Biological name :BCL2A1
  
Synonyms : BCL2A1 / BCL2 related protein A1 / Q16548
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q25.1
Gene start: 79960889
Gene end: 79971446
  
Corresponding Affymetrix probe sets: 205681_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000267953
Ensembl peptide - ENSP00000335250
NCBI entrez gene - 597     See in Manteia.
OMIM - 601056
RefSeq - NM_001114735
RefSeq - NM_004049
RefSeq Peptide - NP_001108207
RefSeq Peptide - NP_004040
swissprot - Q16548
Ensembl - ENSG00000140379
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BCL2A1ENSGALG00000006511Gallus gallus
 Bcl2a1bENSMUSG00000089929Mus musculus
 Bcl2a1cENSMUSG00000053820Mus musculus
 Bcl2a1dENSMUSG00000099974Mus musculus
 Gm29094ENSMUSG00000100838Mus musculus
 Q07440ENSMUSG00000102037Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ST20 / Q9HBF5 / suppressor of tumorigenicity 20ENSG0000018095317


Protein motifs (from Interpro)
Interpro ID Name
 IPR002475  Bcl2-like
 IPR013282  Bcl-2-related protein A1
 IPR020717  Apoptosis regulator, Bcl-2, BH1 motif, conserved site
 IPR020726  Apoptosis regulator, Bcl-2, BH2 motif, conserved site
 IPR026298  Blc2 family
 IPR036834  Blc2-like superfamily


Gene Ontology (GO)
cell communicationcellular component organizationcellular response to stimuluscell deathresponse to stressestablishment of localizationcell communicationcellular component organizationcellular response to stimuluscell deathresponse to stressestablishment of localizationcell communicationcellular component organizationcellular response to stimuluscell deathresponse to stressestablishment of localizationcell communicationcellular component organizationcellular response to stimuluscell deathresponse to stressestablishment of localizationcell communicationcellular component organizationcellular response to stimuluscell deathresponse to stressestablishment of localizationcell communicationcellular component organizationcellular response to stimuluscell deathresponse to stressestablishment of localizationcell communicationcellular component organizationcellular response to stimuluscell deathresponse to stressestablishment of localizationcell communicationcellular component organizationcellular response to stimuluscell deathresponse to stressestablishment of localizationcell communicationcellular component organizationcellular response to stimuluscell deathresponse to stressestablishment of localizationcell communicationcellular component organizationcellular response to stimuluscell deathresponse to stressestablishment of localizationcell communicationcell communicationcellular component orgacellular component organizationcellular response to stcellular response to stimuluscell deathcell deathresponse to stressresponse to stressestablishment of localiestablishment of localization
protein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingprotein bindingtransmembrane transporter activitytransmembrane transporter activity
cellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellcellmembranemembraneorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0001836 release of cytochrome c from mitochondria IBA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008053 mitochondrial fusion IBA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IBA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015267 channel activity IBA
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0046982 protein heterodimerization activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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