ENSG00000140612


Homo sapiens

Features
Gene ID: ENSG00000140612
  
Biological name :SEC11A
  
Synonyms : P67812 / SEC11A / SEC11 homolog A, signal peptidase complex subunit
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q25.3
Gene start: 84669538
Gene end: 84716716
  
Corresponding Affymetrix probe sets: 201290_at (Human Genome U133 Plus 2.0 Array)   216274_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453997
Ensembl peptide - ENSP00000268220
Ensembl peptide - ENSP00000413121
Ensembl peptide - ENSP00000452684
Ensembl peptide - ENSP00000452697
Ensembl peptide - ENSP00000454193
Ensembl peptide - ENSP00000452932
Ensembl peptide - ENSP00000453930
NCBI entrez gene - 23478     See in Manteia.
RefSeq - NM_001271918
RefSeq - NM_001271920
RefSeq - NM_001271921
RefSeq - NM_001271922
RefSeq - NM_014300
RefSeq - NM_001271919
RefSeq Peptide - NP_001258847
RefSeq Peptide - NP_001258849
RefSeq Peptide - NP_001258850
RefSeq Peptide - NP_001258851
RefSeq Peptide - NP_055115
RefSeq Peptide - NP_001258848
swissprot - P67812
swissprot - A0A024RC78
swissprot - H0YKT4
swissprot - H0YNA5
swissprot - H0YNG3
swissprot - H0YNX5
Ensembl - ENSG00000140612
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sec11aENSDARG00000008936Danio rerio
 SEC11AENSGALG00000037553Gallus gallus
 Q9R0P6ENSMUSG00000025724Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9BY50 / SEC11C / SEC11 homolog C, signal peptidase complex subunitENSG0000016656266


Protein motifs (from Interpro)
Interpro ID Name
 IPR001733  Peptidase S26B
 IPR015927  Peptidase S24/S26A/S26B/S26C
 IPR019756  Peptidase S26A, signal peptidase I, serine active site
 IPR019758  Peptidase S26A, signal peptidase I, conserved site
 IPR036286  LexA/Signal peptidase-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006465 signal peptide processing IEA
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005787 signal peptidase complex IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
SRP-dependent cotranslational protein targeting to membrane
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
Synthesis, secretion, and deacylation of Ghrelin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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