ENSG00000141971


Homo sapiens
bindingMVB12Atransportviralescrtcomplexmembranemultivesicularbodydomainproteinbuddingviahostregulationendosomeendosomalvirusmaturationpathwayprocesssortingsubunitumamabpmacroautophagylifecycleassemblyepidermalgrowth

Features
Gene ID: ENSG00000141971
  
Biological name :MVB12A
  
Synonyms : multivesicular body subunit 12A / MVB12A / Q96EY5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.11
Gene start: 17405722
Gene end: 17433724
  
Corresponding Affymetrix probe sets: 227864_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433280
Ensembl peptide - ENSP00000472288
Ensembl peptide - ENSP00000470611
Ensembl peptide - ENSP00000444653
Ensembl peptide - ENSP00000435052
Ensembl peptide - ENSP00000433677
Ensembl peptide - ENSP00000324810
Ensembl peptide - ENSP00000432526
NCBI entrez gene - 93343     See in Manteia.
RefSeq - NM_138401
RefSeq - NM_001304547
RefSeq Peptide - NP_001291476
RefSeq Peptide - NP_612410
swissprot - A0A024R7L6
swissprot - M0QZK6
swissprot - E9PQA6
swissprot - Q96EY5
swissprot - E9PLZ8
swissprot - E9PLL0
swissprot - E9PJW8
Ensembl - ENSG00000141971
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Mvb12aENSMUSG00000031813Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MVB12B / Q9H7P6 / multivesicular body subunit 12BENSG0000019681432


Protein motifs (from Interpro)
Interpro ID Name
 IPR018798  Multivesicular body subunit 12
 IPR023340  UMA domain
 IPR023341  MABP domain


Gene Ontology (GO)
macromolecule localizationestablishment of localizationcellular localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanisminterspecies interaction between organismscellular component organizationcellular component biogenesiscell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulti-organism localizationmacromolecule localizationestablishment of localizationcellular localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanisminterspecies interaction between organismscellular component organizationcellular component biogenesiscell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulti-organism localizationmacromolecule localizationestablishment of localizationcellular localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanisminterspecies interaction between organismscellular component organizationcellular component biogenesiscell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulti-organism localizationmacromolecule localizationestablishment of localizationcellular localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanisminterspecies interaction between organismscellular component organizationcellular component biogenesiscell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulti-organism localizationmacromolecule localizationestablishment of localizationcellular localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanisminterspecies interaction between organismscellular component organizationcellular component biogenesiscell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulti-organism localizationmacromolecule localizationestablishment of localizationcellular localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanisminterspecies interaction between organismscellular component organizationcellular component biogenesiscell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulti-organism localizationmacromolecule localizationestablishment of localizationcellular localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanisminterspecies interaction between organismscellular component organizationcellular component biogenesiscell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulti-organism localizationmacromolecule localizationestablishment of localizationcellular localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanisminterspecies interaction between organismscellular component organizationcellular component biogenesiscell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulti-organism localizationmacromolecule localizationestablishment of localizationcellular localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanisminterspecies interaction between organismscellular component organizationcellular component biogenesiscell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulti-organism localizationmacromolecule localizationestablishment of localizationcellular localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanisminterspecies interaction between organismscellular component organizationcellular component biogenesiscell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processmulti-organism localizationmacromolemacromolecule localizationestablishestablishment of localizationcellular cellular localizationcataboliccatabolic processcellular cellular metabolic processprocess uprocess utilizing autophagic mechanisminterspecinterspecies interaction between organismscellular cellular component organizationcellular cellular component biogenesiscell commcell communicationcellular cellular response to stimulusnitrogen nitrogen compound metabolic processprimary mprimary metabolic processorganic sorganic substance metabolic processmulti-orgmulti-organism localization
protein bindinglipid bindingprotein bindinglipid bindingprotein bindinglipid bindingprotein bindinglipid bindingprotein bindinglipid bindingprotein bindinglipid bindingprotein bindinglipid bindingprotein bindinglipid bindingprotein bindinglipid bindingprotein bindinglipid bindingprotein bindingprotein bindinglipid bindinglipid binding
cellmembraneprotein-containing complexorganellemembrane-enclosed lumenother organismextracellular regioncellmembraneprotein-containing complexorganellemembrane-enclosed lumenother organismextracellular regioncellmembraneprotein-containing complexorganellemembrane-enclosed lumenother organismextracellular regioncellmembraneprotein-containing complexorganellemembrane-enclosed lumenother organismextracellular regioncellmembraneprotein-containing complexorganellemembrane-enclosed lumenother organismextracellular regioncellmembraneprotein-containing complexorganellemembrane-enclosed lumenother organismextracellular regioncellmembraneprotein-containing complexorganellemembrane-enclosed lumenother organismextracellular regioncellmembraneprotein-containing complexorganellemembrane-enclosed lumenother organismextracellular regioncellmembraneprotein-containing complexorganellemembrane-enclosed lumenother organismextracellular regioncellmembraneprotein-containing complexorganellemembrane-enclosed lumenother organismextracellular regioncellcellmembranemembraneprotein-containing cprotein-containing complexorganelleorganellemembrane-enclosed lumembrane-enclosed lumenother organismother organismextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016197 endosomal transport TAS
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0019058 viral life cycle TAS
 biological_processGO:0019075 virus maturation IMP
 biological_processGO:0036258 multivesicular body assembly TAS
 biological_processGO:0039702 viral budding via host ESCRT complex TAS
 biological_processGO:0042058 regulation of epidermal growth factor receptor signaling pathway IMP
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IC
 biological_processGO:0048524 positive regulation of viral process IMP
 biological_processGO:0075733 intracellular transport of virus TAS
 biological_processGO:1903772 regulation of viral budding via host ESCRT complex IMP
 cellular_componentGO:0000813 ESCRT I complex TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0010008 endosome membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0043657 host cell IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IMP
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0043130 ubiquitin binding IMP


Pathways (from Reactome)
Pathway description
Budding and maturation of HIV virion
Membrane binding and targetting of GAG proteins
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000131475 VPS25 / Q9BRG1 / vacuolar protein sorting 25 homolog  / reaction
 ENSG00000074319 Q99816 / TSG101 / tumor susceptibility 101  / complex
 ENSG00000115145 STAM2 / O75886 / signal transducing adaptor molecule 2  / reaction
 ENSG00000159210 SNF8 / Q96H20 / SNF8, ESCRT-II complex subunit  / reaction
 ENSG00000167987 A5D8V6 / VPS37C / VPS37C, ESCRT-I subunit  / complex
 ENSG00000139722 Q9H9H4 / VPS37B / VPS37B, ESCRT-I subunit  / complex
 ENSG00000160948 VPS28 / Q9UK41 / VPS28, ESCRT-I subunit  / complex
 ENSG00000155975 Q8NEZ2 / VPS37A / VPS37A, ESCRT-I subunit  / complex
 ENSG00000176428 Q86XT2 / VPS37D / VPS37D, ESCRT-I subunit  / complex
 ENSG00000185359 HGS / O14964 / hepatocyte growth factor-regulated tyrosine kinase substrate  / reaction
 ENSG00000136100 VPS36 / Q86VN1 / vacuolar protein sorting 36 homolog  / reaction
 ENSG00000136738 STAM / Q92783 / signal transducing adaptor molecule  / reaction






 

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