Manteia

ENSG00000142330

Homo sapiens

Features

Gene ID:	ENSG00000142330

Biological name :	CAPN10

Synonyms :	calpain 10 / CAPN10 / Q9HC96

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	2
Strand:	1
Band:	q37.3
Gene start:	240586716
Gene end:	240617705

Corresponding Affymetrix probe sets:	219333_s_at (Human Genome U133 Plus 2.0 Array) 221040_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000384422 Ensembl peptide - ENSP00000407090 Ensembl peptide - ENSP00000404064 Ensembl peptide - ENSP00000400144 Ensembl peptide - ENSP00000270361 Ensembl peptide - ENSP00000270362 Ensembl peptide - ENSP00000270364 Ensembl peptide - ENSP00000289381 Ensembl peptide - ENSP00000349556 Ensembl peptide - ENSP00000375843 Ensembl peptide - ENSP00000375844 NCBI entrez gene - 11132 See in Manteia. OMIM - 605286 RefSeq - NM_023083 RefSeq - NM_023085 RefSeq Peptide - NP_075571 RefSeq Peptide - NP_075573 swissprot - Q9HC96 swissprot - A0A024R4A1 swissprot - H7C251 swissprot - H7C2P1 swissprot - B7WPF5 Ensembl - ENSG00000142330

Related genetic diseases (OMIM):	601283 - {Diabetes mellitus, noninsulin-dependent 1}, 601283

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
capn10	ENSDARG00000076634	Danio rerio
CAPN10	ENSGALG00000034562	Gallus gallus
Capn10	ENSMUSG00000026270	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
CAPN15 / O75808 / calpain 15	ENSG00000103326	20
CAPN7 / Q9Y6W3 / calpain 7	ENSG00000131375	15

Protein motifs (from Interpro)

Interpro ID	Name
IPR000169	Cysteine peptidase, cysteine active site
IPR001300	Peptidase C2, calpain, catalytic domain
IPR022682	Peptidase C2, calpain, large subunit, domain III
IPR022683	Peptidase C2, calpain, domain III
IPR022684	Peptidase C2, calpain family
IPR028791	Calpain-10
IPR033883	Calpain subdomain III
IPR036213	Calpain large subunit, domain III superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0006921	cellular component disassembly involved in execution phase of apoptosis	IC
biological_process	GO:0031532	actin cytoskeleton reorganization	ISS
biological_process	GO:0032024	positive regulation of insulin secretion	IMP
biological_process	GO:0032388	positive regulation of intracellular transport	ISS
biological_process	GO:0032869	cellular response to insulin stimulus	IEA
biological_process	GO:0046326	positive regulation of glucose import	IMP
biological_process	GO:0097050	type B pancreatic cell apoptotic process	IDA
biological_process	GO:2000676	positive regulation of type B pancreatic cell apoptotic process	IEA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005739	mitochondrion	IDA
cellular_component	GO:0005829	cytosol	ISS
cellular_component	GO:0005886	plasma membrane	ISS
molecular_function	GO:0000149	SNARE binding	ISS
molecular_function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	IEA
molecular_function	GO:0008092	cytoskeletal protein binding	ISS
molecular_function	GO:0008233	peptidase activity	IEA
molecular_function	GO:0008234	cysteine-type peptidase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA

Pathways (from Reactome)

Pathway description

Degradation of the extracellular matrix

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr