ENSG00000143158


Homo sapiens
pyruvateMPC2membranetransmembraneinnerintegralcomponentcarriertransportregulationinsulinsecretioninvolvedcellularresponseglucosestimulusacetyl-coabiosyntheticprocessnucleusmitochondriontransporteractivitymetabolism

Features
Gene ID: ENSG00000143158
  
Biological name :MPC2
  
Synonyms : mitochondrial pyruvate carrier 2 / MPC2 / O95563
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q24.2
Gene start: 167916729
Gene end: 167937040
  
Corresponding Affymetrix probe sets: 202427_s_at (Human Genome U133 Plus 2.0 Array)   227669_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000392874
Ensembl peptide - ENSP00000271373
Ensembl peptide - ENSP00000356820
NCBI entrez gene - 25874     See in Manteia.
OMIM - 614737
RefSeq - XM_006711266
RefSeq - NM_001143674
RefSeq - NM_015415
RefSeq Peptide - NP_001137146
RefSeq Peptide - NP_056230
swissprot - O95563
swissprot - Q5R3B4
swissprot - A0A024R8Z5
Ensembl - ENSG00000143158
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mpc2ENSDARG00000024478Danio rerio
 zgc:103678ENSDARG00000037679Danio rerio
 MPC2ENSGALG00000015437Gallus gallus
 Mpc2ENSMUSG00000026568Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005336  Mitochondrial pyruvate carrier


Gene Ontology (GO)
establishment of localizationcell communicationmacromolecule localizationresponse to chemicalregulation of biological qualitycellular localizationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processestablishment of localizationcell communicationmacromolecule localizationresponse to chemicalregulation of biological qualitycellular localizationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processestablishment of localizationcell communicationmacromolecule localizationresponse to chemicalregulation of biological qualitycellular localizationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processestablishment of localizationcell communicationmacromolecule localizationresponse to chemicalregulation of biological qualitycellular localizationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processestablishment of localizationcell communicationmacromolecule localizationresponse to chemicalregulation of biological qualitycellular localizationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processestablishment of localizationcell communicationmacromolecule localizationresponse to chemicalregulation of biological qualitycellular localizationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processestablishment of localizationcell communicationmacromolecule localizationresponse to chemicalregulation of biological qualitycellular localizationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processestablishment of localizationcell communicationmacromolecule localizationresponse to chemicalregulation of biological qualitycellular localizationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processestablishment of localizationcell communicationmacromolecule localizationresponse to chemicalregulation of biological qualitycellular localizationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processestablishment of localizationcell communicationmacromolecule localizationresponse to chemicalregulation of biological qualitycellular localizationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processestablishmestablishment of localizationcell commucell communicationmacromolecmacromolecule localizationresponse tresponse to chemicalregulationregulation of biological qualitycellular lcellular localizationcellular rcellular response to stimulusnitrogen cnitrogen compound metabolic processbiosynthetbiosynthetic processcellular mcellular metabolic processprimary meprimary metabolic processsmall molesmall molecule metabolic processorganic suorganic substance metabolic process
transmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activity
cellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellcellorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0006850 mitochondrial pyruvate transmembrane transport IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate IEA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031305 integral component of mitochondrial inner membrane IBA
 molecular_functionGO:0050833 pyruvate transmembrane transporter activity IBA


Pathways (from Reactome)
Pathway description
Pyruvate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000060762 MPC1 / Q9Y5U8 / mitochondrial pyruvate carrier 1  / complex






 

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