ENSG00000143199


Homo sapiens
bindingADCY10cyclasecellnucleotideciliumprocessmembraneionactivityadenylatebiosyntheticcytoplasmcytoskeletonpartlyasecalciumadenylylclass-guanylyltetratricopeptide-likehelicaldomainsuperfamilytypep-loopcontainingnucleosidetriphosphatehydrolaseepithelial

Features
Gene ID: ENSG00000143199
  
Biological name :ADCY10
  
Synonyms : ADCY10 / adenylate cyclase 10 / Q96PN6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q24.2
Gene start: 167809388
Gene end: 167914215
  
Corresponding Affymetrix probe sets: 214547_at (Human Genome U133 Plus 2.0 Array)   217305_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356822
Ensembl peptide - ENSP00000441992
Ensembl peptide - ENSP00000475192
Ensembl peptide - ENSP00000476402
Ensembl peptide - ENSP00000356825
NCBI entrez gene - 55811     See in Manteia.
OMIM - 605205
RefSeq - XM_017001778
RefSeq - NM_001167749
RefSeq - NM_001297772
RefSeq - NM_018417
RefSeq - XM_005245330
RefSeq - XM_006711449
RefSeq - XM_011509760
RefSeq - XM_011509762
RefSeq - XM_011509763
RefSeq - XM_011509766
RefSeq Peptide - NP_060887
RefSeq Peptide - NP_001161221
RefSeq Peptide - NP_001284701
swissprot - A0A0K0K1J8
swissprot - Q96PN6
swissprot - U3KPS9
swissprot - V9GY51
Ensembl - ENSG00000143199
  
Related genetic diseases (OMIM): 143870 - {Hypercalciuria, absorptive, susceptibility to}, 143870
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000044949Gallus gallus
 ENSGALG00000044172Gallus gallus
 ENSGALG00000044541Gallus gallus
 ENSGALG00000046496Gallus gallus
 ENSGALG00000046115Gallus gallus
 ENSGALG00000045682Gallus gallus
 ENSGALG00000045245Gallus gallus
 Adcy10ENSMUSG00000026567Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR016577  Adenylate cyclase, type 10
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029787  Nucleotide cyclase


Gene Ontology (GO)
movement of cell or subcellular componentmicrotubule-based processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationcellular response to stimuluscell deathresponse to chemicalmovement of cell or subcellular componentmicrotubule-based processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationcellular response to stimuluscell deathresponse to chemicalmovement of cell or subcellular componentmicrotubule-based processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationcellular response to stimuluscell deathresponse to chemicalmovement of cell or subcellular componentmicrotubule-based processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationcellular response to stimuluscell deathresponse to chemicalmovement of cell or subcellular componentmicrotubule-based processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationcellular response to stimuluscell deathresponse to chemicalmovement of cell or subcellular componentmicrotubule-based processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationcellular response to stimuluscell deathresponse to chemicalmovement of cell or subcellular componentmicrotubule-based processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationcellular response to stimuluscell deathresponse to chemicalmovement of cell or subcellular componentmicrotubule-based processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationcellular response to stimuluscell deathresponse to chemicalmovement of cell or subcellular componentmicrotubule-based processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationcellular response to stimuluscell deathresponse to chemicalmovement of cell or subcellular componentmicrotubule-based processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processmulticellular organism reproductioncell communicationcellular response to stimuluscell deathresponse to chemicalmovement omovement of cell or subcellular componentmicrotubulmicrotubule-based processnitrogen cnitrogen compound metabolic processbiosynthetbiosynthetic processcellular mcellular metabolic processprimary meprimary metabolic processsmall molesmall molecule metabolic processorganic suorganic substance metabolic processmulticellumulticellular organism reproductioncell commucell communicationcellular rcellular response to stimuluscell deathcell deathresponse tresponse to chemical
organic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcyclase activitylyase activityprotein bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcyclase activitylyase activityprotein bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcyclase activitylyase activityprotein bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcyclase activitylyase activityprotein bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcyclase activitylyase activityprotein bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcyclase activitylyase activityprotein bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcyclase activitylyase activityprotein bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcyclase activitylyase activityprotein bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcyclase activitylyase activityprotein bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingion bindingcyclase activitylyase activityprotein bindingcarbohydrate derivative bindingdrug bindingorganic cyclic organic cyclic compound bindingheterocyclic coheterocyclic compound bindingsmall molecule small molecule bindingion bindingion bindingcyclase activitcyclase activitylyase activitylyase activityprotein bindingprotein bindingcarbohydrate decarbohydrate derivative bindingdrug bindingdrug binding
cellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellcellorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0003351 epithelial cilium movement IMP
 biological_processGO:0006171 cAMP biosynthetic process NAS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0071241 cellular response to inorganic substance IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol NAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031514 motile cilium IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0045178 basal part of cell IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004016 adenylate cyclase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051117 ATPase binding IEA
 molecular_functionGO:0071890 bicarbonate binding IDA


Pathways (from Reactome)
Pathway description
Hedgehog off state


Phenotype (from MGI, Zfin or HPO)
Abnormality of the musculoskeletal systemMetabolism abnormalityGenitourinary abnormalityAbnormality of the musculoskeletal systemMetabolism abnormalityGenitourinary abnormalityAbnormality of the musculoskeletal systemMetabolism abnormalityGenitourinary abnormalityAbnormality of the musculoskeletal systemMetabolism abnormalityGenitourinary abnormalityAbnormality of the musculoskeletal systemMetabolism abnormalityGenitourinary abnormalityAbnormality of the musculoskeletal systemMetabolism abnormalityGenitourinary abnormalityAbnormality of the musculoskeletal systemMetabolism abnormalityGenitourinary abnormalityAbnormality of the musculoskeletal systemMetabolism abnormalityGenitourinary abnormalityAbnormality of the musculoskeletal systemMetabolism abnormalityGenitourinary abnormalityAbnormality of the musculoskeletal systemMetabolism abnormalityGenitourinary abnormalityAbnormality of the musculoskeletal systemAbnormality of the musculoskeletal systemMetabolism abnormalityMetabolism abnormalityGenitourinary abnormalityGenitourinary abnormality
IDPhenotypeDefinition Genetic BG
 HP:0000938 Osteopenia "Osteopenia refers to a reduction in bone mineral density (BMD) below normal peak BMD but not low enough to be classified as osteoporosis. According to the WHO, osteopenia is characterized by a value of BMD more than 1 standard deviation below the young adult mean, but less than 2 standard deviations below this value." [HPO:curators]
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 HP:0000939 Osteoporosis "Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO, osteoporosis is characterized by a value of BMD 2.5 standard deviations or more below the young adult mean." [HPO:curators]
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 HP:0002150 Hypercalciuria 
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 HP:0008672 Calcium oxalate nephrolithiasis 
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 HP:0012637 Renal calcium wasting "High urine calcium in the presence of hypocalcemia." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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