ENSG00000144681


Homo sapiens
domainproteinregulationchannelbindingSTACshsignaltransductionactivityionkinasec-likephorbolesterdiacylglycerol-bindingstac-likesuperfamilymusclecontractioncellularresponseheatintracellularvoltage-gatedcalciumlocalizationplasmamembranecation

Features
Gene ID: ENSG00000144681
  
Biological name :STAC
  
Synonyms : Q99469 / SH3 and cysteine rich domain / STAC
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p22.3
Gene start: 36380344
Gene end: 36548007
  
Corresponding Affymetrix probe sets: 205743_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000397521
Ensembl peptide - ENSP00000398403
Ensembl peptide - ENSP00000273183
Ensembl peptide - ENSP00000393713
NCBI entrez gene - 6769     See in Manteia.
OMIM - 602317
RefSeq - XM_017007084
RefSeq - NM_001292049
RefSeq - NM_003149
RefSeq - XM_011534036
RefSeq - XM_011534037
RefSeq - XM_011534038
RefSeq - XM_017007083
RefSeq Peptide - NP_001278978
RefSeq Peptide - NP_003140
swissprot - E9PEA7
swissprot - F8WB25
swissprot - Q99469
swissprot - C9J3Z9
Ensembl - ENSG00000144681
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stacENSDARG00000074004Danio rerio
 STACENSGALG00000039092Gallus gallus
 StacENSMUSG00000032502Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STAC2 / Q6ZMT1 / SH3 and cysteine rich domain 2ENSG0000014175044
STAC3 / Q96MF2 / SH3 and cysteine rich domain 3ENSG0000018548233


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR035508  STAC1
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
system processcell communicationcellular response to stimulusresponse to stressresponse to abiotic stimulusestablishment of localizationregulation of molecular functionmacromolecule localizationcellular localizationsystem processcell communicationcellular response to stimulusresponse to stressresponse to abiotic stimulusestablishment of localizationregulation of molecular functionmacromolecule localizationcellular localizationsystem processcell communicationcellular response to stimulusresponse to stressresponse to abiotic stimulusestablishment of localizationregulation of molecular functionmacromolecule localizationcellular localizationsystem processcell communicationcellular response to stimulusresponse to stressresponse to abiotic stimulusestablishment of localizationregulation of molecular functionmacromolecule localizationcellular localizationsystem processcell communicationcellular response to stimulusresponse to stressresponse to abiotic stimulusestablishment of localizationregulation of molecular functionmacromolecule localizationcellular localizationsystem processcell communicationcellular response to stimulusresponse to stressresponse to abiotic stimulusestablishment of localizationregulation of molecular functionmacromolecule localizationcellular localizationsystem processcell communicationcellular response to stimulusresponse to stressresponse to abiotic stimulusestablishment of localizationregulation of molecular functionmacromolecule localizationcellular localizationsystem processcell communicationcellular response to stimulusresponse to stressresponse to abiotic stimulusestablishment of localizationregulation of molecular functionmacromolecule localizationcellular localizationsystem processcell communicationcellular response to stimulusresponse to stressresponse to abiotic stimulusestablishment of localizationregulation of molecular functionmacromolecule localizationcellular localizationsystem processcell communicationcellular response to stimulusresponse to stressresponse to abiotic stimulusestablishment of localizationregulation of molecular functionmacromolecule localizationcellular localizationsystem processsystem processcell communicatcell communicationcellular responcellular response to stimulusresponse to strresponse to stressresponse to abiresponse to abiotic stimulusestablishment oestablishment of localizationregulation of mregulation of molecular functionmacromolecule lmacromolecule localizationcellular localicellular localization
protein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingion bindingprotein bindingprotein bindingion bindingion binding
cellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellcellmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction IEA
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:1901385 regulation of voltage-gated calcium channel activity IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:2001259 positive regulation of cation channel activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol NAS
 cellular_componentGO:0030315 T-tubule IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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