ENSG00000148248


Homo sapiens
membraneSURF4golgiendoplasmicretrogradetransportorganizationneutrophildegranulationreticulumreticulum-golgiintermediatecompartmentsurfeitlocusvesicle-mediatederregulationorganelleapparatusplasmaintegralcomponentvesicleazurophilgranuleproteinbindingcopi-dependentgolgi-to-ertraffic

Features
Gene ID: ENSG00000148248
  
Biological name :SURF4
  
Synonyms : O15260 / SURF4 / surfeit 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q34.2
Gene start: 133361449
Gene end: 133376166
  
Corresponding Affymetrix probe sets: 222977_at (Human Genome U133 Plus 2.0 Array)   222978_at (Human Genome U133 Plus 2.0 Array)   222979_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481666
Ensembl peptide - ENSP00000446061
Ensembl peptide - ENSP00000483216
Ensembl peptide - ENSP00000361057
Ensembl peptide - ENSP00000361059
Ensembl peptide - ENSP00000419853
NCBI entrez gene - 6836     See in Manteia.
OMIM - 185660
RefSeq - XM_017015062
RefSeq - NM_001280788
RefSeq - NM_001280789
RefSeq - NM_001280790
RefSeq - NM_001280791
RefSeq - NM_001280792
RefSeq - NM_001280793
RefSeq - NM_033161
RefSeq - XM_011518943
RefSeq - XM_011518944
RefSeq - XM_011518945
RefSeq Peptide - NP_001267720
RefSeq Peptide - NP_001267721
RefSeq Peptide - NP_001267722
RefSeq Peptide - NP_149351
RefSeq Peptide - NP_001267717
RefSeq Peptide - NP_001267718
RefSeq Peptide - NP_001267719
swissprot - O15260
swissprot - Q5T8U5
swissprot - B7Z1G8
Ensembl - ENSG00000148248
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 surf4lENSDARG00000035131Danio rerio
 SURF4ENSGALG00000028265Gallus gallus
 Surf4ENSMUSG00000014867Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002995  Surfeit locus 4


Gene Ontology (GO)
establishment of localizationcellular component organizationimmune responsecell activationimmune effector processestablishment of localizationcellular component organizationimmune responsecell activationimmune effector processestablishment of localizationcellular component organizationimmune responsecell activationimmune effector processestablishment of localizationcellular component organizationimmune responsecell activationimmune effector processestablishment of localizationcellular component organizationimmune responsecell activationimmune effector processestablishment of localizationcellular component organizationimmune responsecell activationimmune effector processestablishment of localizationcellular component organizationimmune responsecell activationimmune effector processestablishment of localizationcellular component organizationimmune responsecell activationimmune effector processestablishment of localizationcellular component organizationimmune responsecell activationimmune effector processestablishment of localizationcellular component organizationimmune responsecell activationimmune effector processestablishment of localizatioestablishment of localizationcellular component organizatcellular component organizationimmune responseimmune responsecell activationcell activationimmune effector processimmune effector process
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellcellmembranemembraneorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS
 biological_processGO:0007030 Golgi organization IMP
 biological_processGO:0010638 positive regulation of organelle organization IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030133 transport vesicle TAS
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA
 cellular_componentGO:0035577 azurophil granule membrane TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000086598 TMED2 / Q15363 / transmembrane p24 trafficking protein 2  / complex
 ENSG00000170348 P49755 / TMED10 / transmembrane p24 trafficking protein 10  / complex
 ENSG00000184840 TMED9 / Q9BVK6 / transmembrane p24 trafficking protein 9  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr