ENSG00000149273


Homo sapiens

Features
Gene ID: ENSG00000149273
  
Biological name :RPS3
  
Synonyms : P23396 / ribosomal protein S3 / RPS3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.4
Gene start: 75399486
Gene end: 75422280
  
Corresponding Affymetrix probe sets: 208692_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433421
Ensembl peptide - ENSP00000433821
Ensembl peptide - ENSP00000437105
Ensembl peptide - ENSP00000436971
Ensembl peptide - ENSP00000436556
Ensembl peptide - ENSP00000436476
Ensembl peptide - ENSP00000436335
Ensembl peptide - ENSP00000435566
Ensembl peptide - ENSP00000435457
Ensembl peptide - ENSP00000434643
Ensembl peptide - ENSP00000278572
Ensembl peptide - ENSP00000416745
Ensembl peptide - ENSP00000431737
Ensembl peptide - ENSP00000431834
Ensembl peptide - ENSP00000432458
Ensembl peptide - ENSP00000432542
Ensembl peptide - ENSP00000433155
NCBI entrez gene - 6188     See in Manteia.
OMIM - 600454
RefSeq - NM_001256802
RefSeq - NM_001260506
RefSeq - NM_001260507
RefSeq - NM_001005
RefSeq Peptide - NP_001243731
RefSeq Peptide - NP_001247435
RefSeq Peptide - NP_001247436
RefSeq Peptide - NP_000996
swissprot - F2Z2S8
swissprot - H0YCJ7
swissprot - H0YES8
swissprot - H0YEU2
swissprot - H0YF32
swissprot - E9PSF4
swissprot - P23396
swissprot - E9PQX2
swissprot - E9PQ96
swissprot - E9PPU1
swissprot - E9PL09
swissprot - E9PK82
swissprot - E9PJN9
swissprot - E9PJH4
Ensembl - ENSG00000149273
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps3ENSDARG00000103007Danio rerio
 RPS3ENSGALG00000017330Gallus gallus
 Rps3ENSMUSG00000030744Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001351  Ribosomal protein S3, C-terminal
 IPR004044  K Homology domain, type 2
 IPR005703  Ribosomal protein S3, eukaryotic/archaeal
 IPR009019  K homology domain superfamily, prokaryotic type
 IPR015946  K homology domain-like, alpha/beta
 IPR018280  Ribosomal protein S3, conserved site
 IPR036419  Ribosomal protein S3, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0002181 cytoplasmic translation IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation TAS
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEP
 biological_processGO:0006979 response to oxidative stress IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0017148 negative regulation of translation IDA
 biological_processGO:0019083 viral transcription TAS
 biological_processGO:0031116 positive regulation of microtubule polymerization IMP
 biological_processGO:0031334 positive regulation of protein complex assembly IMP
 biological_processGO:0031397 negative regulation of protein ubiquitination IDA
 biological_processGO:0032079 positive regulation of endodeoxyribonuclease activity IDA
 biological_processGO:0032743 positive regulation of interleukin-2 production IMP
 biological_processGO:0042104 positive regulation of activated T cell proliferation IMP
 biological_processGO:0042769 DNA damage response, detection of DNA damage IMP
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0043507 positive regulation of JUN kinase activity IMP
 biological_processGO:0045738 negative regulation of DNA repair IMP
 biological_processGO:0045739 positive regulation of DNA repair IDA
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0051225 spindle assembly IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0061481 response to TNF agonist IDA
 biological_processGO:0070301 cellular response to hydrogen peroxide IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IMP
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IDA
 biological_processGO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:1902546 positive regulation of DNA N-glycosylase activity IDA
 biological_processGO:1905053 positive regulation of base-excision repair IDA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IDA
 biological_processGO:2001272 positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis IMP
 cellular_componentGO:0005634 nucleus IMP
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IMP
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0005844 polysome IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0015935 small ribosomal subunit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0022627 cytosolic small ribosomal subunit IDA
 cellular_componentGO:0032587 ruffle membrane IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071159 NF-kappaB complex IDA
 cellular_componentGO:0072686 mitotic spindle IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0003735 structural constituent of ribosome IEA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0004520 endodeoxyribonuclease activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0015631 tubulin binding IDA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030544 Hsp70 protein binding IDA
 molecular_functionGO:0032357 oxidized purine DNA binding IDA
 molecular_functionGO:0032358 oxidized pyrimidine DNA binding IDA
 molecular_functionGO:0044390 ubiquitin-like protein conjugating enzyme binding IPI
 molecular_functionGO:0044877 protein-containing complex binding IMP
 molecular_functionGO:0051018 protein kinase A binding IPI
 molecular_functionGO:0051536 iron-sulfur cluster binding NAS
 molecular_functionGO:0051879 Hsp90 protein binding IDA
 molecular_functionGO:0070181 small ribosomal subunit rRNA binding IDA
 molecular_functionGO:0097100 supercoiled DNA binding IDA
 molecular_functionGO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0140080 class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity IEA


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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