ENSG00000151322


Homo sapiens
NPAS3pasdomaindna-templatedregulationbindinghelix-loop-helixsuperfamilyrnapolymeraseiiactivitydnaproteinmyc-typebasicbhlhfold-folddna-bindingdevelopmentalprocessnucleusnucleoplasmcytosolfactorsequence-specificdimerization

Features
Gene ID: ENSG00000151322
  
Biological name :NPAS3
  
Synonyms : neuronal PAS domain protein 3 / NPAS3 / Q8IXF0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q13.1
Gene start: 32934933
Gene end: 33804176
  
Corresponding Affymetrix probe sets: 1554635_a_at (Human Genome U133 Plus 2.0 Array)   1569661_at (Human Genome U133 Plus 2.0 Array)   220316_at (Human Genome U133 Plus 2.0 Array)   222172_at (Human Genome U133 Plus 2.0 Array)   229281_at (Human Genome U133 Plus 2.0 Array)   230412_at (Human Genome U133 Plus 2.0 Array)   233293_at (Human Genome U133 Plus 2.0 Array)   233865_at (Human Genome U133 Plus 2.0 Array)   234014_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450392
Ensembl peptide - ENSP00000448916
Ensembl peptide - ENSP00000449542
Ensembl peptide - ENSP00000319610
Ensembl peptide - ENSP00000348460
Ensembl peptide - ENSP00000350446
Ensembl peptide - ENSP00000446700
Ensembl peptide - ENSP00000447213
Ensembl peptide - ENSP00000447858
Ensembl peptide - ENSP00000448373
Ensembl peptide - ENSP00000448450
NCBI entrez gene - 64067     See in Manteia.
OMIM - 609430
RefSeq - XM_017021588
RefSeq - XM_005267991
RefSeq - XM_005267992
RefSeq - XM_011537067
RefSeq - XM_011537069
RefSeq - XM_011537070
RefSeq - XM_011537071
RefSeq - XM_011537072
RefSeq - XM_017021582
RefSeq - XM_017021583
RefSeq - XM_017021584
RefSeq - XM_017021585
RefSeq - XM_017021586
RefSeq - XM_017021587
RefSeq - NM_001164749
RefSeq - NM_001165893
RefSeq - NM_022123
RefSeq - NM_173159
RefSeq Peptide - NP_001158221
RefSeq Peptide - NP_001159365
RefSeq Peptide - NP_071406
RefSeq Peptide - NP_775182
swissprot - H0YI42
swissprot - Q8IXF0
swissprot - F8VS42
swissprot - X5D988
swissprot - F8VR32
swissprot - X5D2Q4
swissprot - F8W0C2
swissprot - H0YHB6
swissprot - H0YHU7
Ensembl - ENSG00000151322
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NPAS3ENSDARG00000109820Danio rerio
 NPAS3ENSGALG00000029022Gallus gallus
 Npas3ENSMUSG00000021010Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NPAS1 / Q99742 / neuronal PAS domain protein 1ENSG0000013075131
SIM1 / P81133 / single-minded family bHLH transcription factor 1ENSG0000011224623
SIM2 / Q14190 / single-minded family bHLH transcription factor 2ENSG0000015926323
HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunitENSG0000010064420
EPAS1 / Q99814 / endothelial PAS domain protein 1ENSG0000011601620
HIF3A / Q9Y2N7 / hypoxia inducible factor 3 alpha subunitENSG0000012444018
ARNT2 / Q9HBZ2 / aryl hydrocarbon receptor nuclear translocator 2ENSG0000017237913
ARNT / P27540 / aryl hydrocarbon receptor nuclear translocatorENSG0000014343712
ARNTL2 / Q8WYA1 / aryl hydrocarbon receptor nuclear translocator like 2ENSG0000002915311
ARNTL / O00327 / aryl hydrocarbon receptor nuclear translocator likeENSG0000013379411
CLOCK / O15516 / clock circadian regulatorENSG0000013485211
NPAS2 / Q99743 / neuronal PAS domain protein 2ENSG0000017048510


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013655  PAS fold-3
 IPR013767  PAS fold
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic nitrogen compound metabolic processbiosynthetic processbiosynthetic processcellular metabolic processcellular metabolic processprimary metabolic processprimary metabolic processorganic substance metabolic organic substance metabolic process
DNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingprotein bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingprotein bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingprotein bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingprotein bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingprotein bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingprotein bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingprotein bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingprotein bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingprotein bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingprotein bindingDNA-binding transcription factor acDNA-binding transcription factor activityorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound bindingprotein bindingprotein binding
cellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumen
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0032502 developmental process IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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