ENSG00000153487


Homo sapiens

Features
Gene ID: ENSG00000153487
  
Biological name :ING1
  
Synonyms : ING1 / inhibitor of growth family member 1 / Q9UK53
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q34
Gene start: 110712736
Gene end: 110723339
  
Corresponding Affymetrix probe sets: 208415_x_at (Human Genome U133 Plus 2.0 Array)   209808_x_at (Human Genome U133 Plus 2.0 Array)   210350_x_at (Human Genome U133 Plus 2.0 Array)   244177_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000480985
Ensembl peptide - ENSP00000345202
Ensembl peptide - ENSP00000364929
Ensembl peptide - ENSP00000364930
Ensembl peptide - ENSP00000328436
NCBI entrez gene - 3621     See in Manteia.
OMIM - 601566
RefSeq - NM_005537
RefSeq - NM_001267728
RefSeq - NM_198217
RefSeq - NM_198218
RefSeq - NM_198219
RefSeq Peptide - NP_937862
RefSeq Peptide - NP_005528
RefSeq Peptide - NP_937860
RefSeq Peptide - NP_937861
RefSeq Peptide - NP_001254657
swissprot - Q9UK53
swissprot - A0A0C4DFW2
swissprot - A0A087WXF7
Ensembl - ENSG00000153487
  
Related genetic diseases (OMIM): 275355 - Squamous cell carcinoma, head and neck, somatic, 275355
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ing1ENSDARG00000019116Danio rerio
 ING1ENSGALG00000016849Gallus gallus
 Ing1ENSMUSG00000045969Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ING2 / Q9H160 / inhibitor of growth family member 2ENSG0000016855634
ING4 / Q9UNL4 / inhibitor of growth family member 4ENSG0000011165320
ING3 / Q9NXR8 / inhibitor of growth family member 3ENSG0000007124318
ING5 / Q8WYH8 / inhibitor of growth family member 5ENSG0000016839510


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR024610  Inhibitor of growth protein, N-terminal histone-binding
 IPR028643  Inhibitor of growth protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010941 regulation of cell death IEA
 biological_processGO:0030308 negative regulation of cell growth NAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0002860 Squamous cell carcinoma 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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