ENSG00000154305


Homo sapiens
transportproteinMIA3regulationmembraneendoplasmicreticulumshdomainmigrationergolgivesicle-mediatedcelllipoproteinpost-translationalcargobindinginsulin-likegrowthfactor-likesuperfamilyleukocyteexocytosisadhesionwoundhealingmodificationcellularmetabolic

Features
Gene ID: ENSG00000154305
  
Biological name :MIA3
  
Synonyms : MIA3 / MIA family member 3, ER export factor / Q5JRA6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q41
Gene start: 222618086
Gene end: 222668012
  
Corresponding Affymetrix probe sets: 1569057_s_at (Human Genome U133 Plus 2.0 Array)   212305_s_at (Human Genome U133 Plus 2.0 Array)   212310_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000340900
Ensembl peptide - ENSP00000345866
Ensembl peptide - ENSP00000355062
Ensembl peptide - ENSP00000396598
Ensembl peptide - ENSP00000341348
NCBI entrez gene - 375056     See in Manteia.
OMIM - 613455
RefSeq - XM_017001243
RefSeq - NM_001300867
RefSeq - NM_001324062
RefSeq - NM_001324063
RefSeq - NM_001324064
RefSeq - NM_001324065
RefSeq - NM_198551
RefSeq - XM_006711304
RefSeq - XM_011509513
RefSeq Peptide - NP_001287796
RefSeq Peptide - NP_001310994
RefSeq Peptide - NP_940953
RefSeq Peptide - NP_001310991
RefSeq Peptide - NP_001310992
RefSeq Peptide - NP_001310993
swissprot - H7C0T4
swissprot - Q5JRA6
swissprot - A0A0A0MRH6
Ensembl - ENSG00000154305
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mia3ENSDARG00000008184Danio rerio
 MIA3ENSGALG00000041034Gallus gallus
 Mia3ENSMUSG00000056050Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTAGE5 / O15320 / Q96PC5 / CTAGE family member 5, ER export factorENSG0000015052712
CTAGE4 / Q8IX94 / CTAGE family member 4ENSG0000022593211
A4FU28 / CTAGE9 / CTAGE family member 9ENSG0000023676111
CTAGE8 / P0CG41 / CTAGE family member 8ENSG0000024469311
A4D2H0 / CTAGE15 / CTAGE family member 15ENSG0000027107911
CTAGE6 / Q86UF2 / CTAGE family member 6ENSG0000027132111
CTAGE1 / Q96RT6 / Q9HC47 / cutaneous T cell lymphoma-associated antigen 1ENSG0000021271010


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
localization of cellmovement of cell or subcellular componentestablishment of localizationcellular localizationcell adhesionmacromolecule localizationresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentestablishment of localizationcellular localizationcell adhesionmacromolecule localizationresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentestablishment of localizationcellular localizationcell adhesionmacromolecule localizationresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentestablishment of localizationcellular localizationcell adhesionmacromolecule localizationresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentestablishment of localizationcellular localizationcell adhesionmacromolecule localizationresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentestablishment of localizationcellular localizationcell adhesionmacromolecule localizationresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentestablishment of localizationcellular localizationcell adhesionmacromolecule localizationresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentestablishment of localizationcellular localizationcell adhesionmacromolecule localizationresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentestablishment of localizationcellular localizationcell adhesionmacromolecule localizationresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesislocalization of cellmovement of cell or subcellular componentestablishment of localizationcellular localizationcell adhesionmacromolecule localizationresponse to stressnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcellular component biogenesislocalizatilocalization of cellmovement omovement of cell or subcellular componentestablishmestablishment of localizationcellular lcellular localizationcell adhescell adhesionmacromolecmacromolecule localizationresponse tresponse to stressnitrogen cnitrogen compound metabolic processcellular mcellular metabolic processprimary meprimary metabolic processorganic suorganic substance metabolic processcellular ccellular component organizationcellular ccellular component biogenesis
protein bindingprotein transporter activityprotein bindingprotein transporter activityprotein bindingprotein transporter activityprotein bindingprotein transporter activityprotein bindingprotein transporter activityprotein bindingprotein transporter activityprotein bindingprotein transporter activityprotein bindingprotein transporter activityprotein bindingprotein transporter activityprotein bindingprotein transporter activityprotein bindingprotein bindingprotein transporter activityprotein transporter activity
cellmembraneorganellemembrane-enclosed lumencellmembraneorganellemembrane-enclosed lumencellmembraneorganellemembrane-enclosed lumencellmembraneorganellemembrane-enclosed lumencellmembraneorganellemembrane-enclosed lumencellmembraneorganellemembrane-enclosed lumencellmembraneorganellemembrane-enclosed lumencellmembraneorganellemembrane-enclosed lumencellmembraneorganellemembrane-enclosed lumencellmembraneorganellemembrane-enclosed lumencellcellmembranemembraneorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumen
TypeGO IDTermEv.Code
 biological_processGO:0002687 positive regulation of leukocyte migration IDA
 biological_processGO:0006887 exocytosis IMP
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0007162 negative regulation of cell adhesion IDA
 biological_processGO:0015031 protein transport IMP
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0030336 negative regulation of cell migration IDA
 biological_processGO:0042060 wound healing IDA
 biological_processGO:0042953 lipoprotein transport IMP
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0090110 cargo loading into COPII-coated vesicle IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070971 endoplasmic reticulum exit site IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042954 lipoprotein transporter activity IMP


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Cargo concentration in the ER
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138073 PREB / Q9HCU5 / prolactin regulatory element binding  / complex / reaction
 ENSG00000150527 CTAGE5 / O15320 / Q96PC5 / CTAGE family member 5, ER export factor  / complex / reaction
 ENSG00000100934 Q15436 / SEC23A / Sec23 homolog A, coat complex II component  / complex / reaction
 ENSG00000176986 P53992 / SEC24C / SEC24 homolog C, COPII coat complex component  / complex / reaction






 

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