ENSG00000157150


Homo sapiens

Features
Gene ID: ENSG00000157150
  
Biological name :TIMP4
  
Synonyms : Q99727 / TIMP4 / TIMP metallopeptidase inhibitor 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p25.2
Gene start: 12153051
Gene end: 12159351
  
Corresponding Affymetrix probe sets: 206243_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000287814
NCBI entrez gene - 7079     See in Manteia.
OMIM - 601915
RefSeq - NM_003256
RefSeq Peptide - NP_003247
swissprot - Q99727
Ensembl - ENSG00000157150
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 timp4.1ENSDARG00000111805Danio rerio
 TIMP4ENSGALG00000004969Gallus gallus
 Timp4ENSMUSG00000030317Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TIMP2 / P16035 / TIMP metallopeptidase inhibitor 2ENSG0000003586246
TIMP3 / P35625 / TIMP metallopeptidase inhibitor 3ENSG0000010023444
TIMP1 / P01033 / TIMP metallopeptidase inhibitor 1ENSG0000010226522


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR001820  Protease inhibitor I35 (TIMP)
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015614  Metalloproteinase inhibitor 4
 IPR027465  Proteinase inhibitor I35b (TIMP), C-terminal
 IPR030490  Tissue inhibitor of metalloproteinase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042698 ovulation cycle IEA
 biological_processGO:0043086 negative regulation of catalytic activity IBA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0051045 negative regulation of membrane protein ectodomain proteolysis IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0030017 sarcomere IEA
 molecular_functionGO:0002020 protease binding IBA
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008191 metalloendopeptidase inhibitor activity IBA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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