ENSG00000157954


Homo sapiens
proteinassemblyWIPI2wddomainautophagosomeautophagyphagophoresitemembranebindingrepeatsuperfamilylipidationmacroautophagyphosphatidylinositol-yvtnrepeat-like-containingphosphoinositide-interacting-repeat-containingmitochondrionlocalizationnucleusinvolvedxenophagynucleoplasmcytosolextrinsiccomponentprotein-containingcomplex

Features
Gene ID: ENSG00000157954
  
Biological name :WIPI2
  
Synonyms : Q9Y4P8 / WD repeat domain, phosphoinositide interacting 2 / WIPI2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p22.1
Gene start: 5190188
Gene end: 5233826
  
Corresponding Affymetrix probe sets: 1570033_at (Human Genome U133 Plus 2.0 Array)   202031_s_at (Human Genome U133 Plus 2.0 Array)   204710_s_at (Human Genome U133 Plus 2.0 Array)   214699_x_at (Human Genome U133 Plus 2.0 Array)   226986_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000288828
Ensembl peptide - ENSP00000384945
Ensembl peptide - ENSP00000385297
Ensembl peptide - ENSP00000429654
Ensembl peptide - ENSP00000371821
NCBI entrez gene - 26100     See in Manteia.
OMIM - 609225
RefSeq - XM_017011952
RefSeq - NM_001033518
RefSeq - NM_001033519
RefSeq - NM_001033520
RefSeq - NM_001278299
RefSeq - NM_015610
RefSeq - NM_016003
RefSeq - XM_006715685
RefSeq Peptide - NP_001028690
RefSeq Peptide - NP_001028692
RefSeq Peptide - NP_001265228
RefSeq Peptide - NP_056425
RefSeq Peptide - NP_057087
RefSeq Peptide - NP_001028691
swissprot - A0A024R823
swissprot - Q9Y4P8
Ensembl - ENSG00000157954
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wipi2ENSDARG00000037871Danio rerio
 WIPI2ENSGALG00000004557Gallus gallus
 Wipi2ENSMUSG00000029578Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WIPI1 / Q5MNZ9 / WD repeat domain, phosphoinositide interacting 1ENSG0000007054052


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR032911  WD repeat domain phosphoinositide-interacting protein 2
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
catabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processmacromolecule localizationcellular localizationresponse to stressresponse to external stimulusresponse to biotic stimuluscatabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processmacromolecule localizationcellular localizationresponse to stressresponse to external stimulusresponse to biotic stimuluscatabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processmacromolecule localizationcellular localizationresponse to stressresponse to external stimulusresponse to biotic stimuluscatabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processmacromolecule localizationcellular localizationresponse to stressresponse to external stimulusresponse to biotic stimuluscatabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processmacromolecule localizationcellular localizationresponse to stressresponse to external stimulusresponse to biotic stimuluscatabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processmacromolecule localizationcellular localizationresponse to stressresponse to external stimulusresponse to biotic stimuluscatabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processmacromolecule localizationcellular localizationresponse to stressresponse to external stimulusresponse to biotic stimuluscatabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processmacromolecule localizationcellular localizationresponse to stressresponse to external stimulusresponse to biotic stimuluscatabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processmacromolecule localizationcellular localizationresponse to stressresponse to external stimulusresponse to biotic stimuluscatabolic processcellular component organizationcellular component biogenesiscellular metabolic processprocess utilizing autophagic mechanismnitrogen compound metabolic processbiosynthetic processprimary metabolic processorganic substance metabolic processmacromolecule localizationcellular localizationresponse to stressresponse to external stimulusresponse to biotic stimuluscatabolic catabolic processcellular ccellular component organizationcellular ccellular component biogenesiscellular mcellular metabolic processprocess utprocess utilizing autophagic mechanismnitrogen cnitrogen compound metabolic processbiosynthetbiosynthetic processprimary meprimary metabolic processorganic suorganic substance metabolic processmacromolecmacromolecule localizationcellular lcellular localizationresponse tresponse to stressresponse tresponse to external stimulusresponse tresponse to biotic stimulus
protein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindinglipid bindingion bindingprotein bindingprotein bindinglipid bindinglipid bindingion bindingion binding
cellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenmembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IMP
 biological_processGO:0000422 autophagy of mitochondrion IBA
 biological_processGO:0006497 protein lipidation IBA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0034497 protein localization to phagophore assembly site IBA
 biological_processGO:0044804 autophagy of nucleus IBA
 biological_processGO:0061739 protein lipidation involved in autophagosome assembly IEA
 biological_processGO:0098792 xenophagy IEA
 cellular_componentGO:0000407 phagophore assembly site IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0019898 extrinsic component of membrane IBA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0034045 phagophore assembly site membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding IDA
 molecular_functionGO:0080025 phosphatidylinositol-3,5-bisphosphate binding IDA


Pathways (from Reactome)
Pathway description
Macroautophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000057663 ATG5 / Q9H1Y0 / autophagy related 5  / complex / reaction
 ENSG00000085978 Q676U5 / ATG16L1 / autophagy related 16 like 1  / complex / reaction
 ENSG00000145782 ATG12 / O94817 / autophagy related 12  / complex / reaction






 

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