ENSG00000158019


Homo sapiens

Features
Gene ID: ENSG00000158019
  
Biological name :BABAM2
  
Synonyms : BABAM2 / BRISC and BRCA1 A complex member 2 / Q9NXR7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p23.2
Gene start: 27889941
Gene end: 28338901
  
Corresponding Affymetrix probe sets: 205550_s_at (Human Genome U133 Plus 2.0 Array)   211566_x_at (Human Genome U133 Plus 2.0 Array)   212645_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000368953
Ensembl peptide - ENSP00000368950
Ensembl peptide - ENSP00000392345
Ensembl peptide - ENSP00000474342
Ensembl peptide - ENSP00000339371
Ensembl peptide - ENSP00000343412
Ensembl peptide - ENSP00000354699
Ensembl peptide - ENSP00000368945
NCBI entrez gene - 9577     See in Manteia.
OMIM - 610497
RefSeq - NM_001329112
RefSeq - NM_001261840
RefSeq - NM_004899
RefSeq - NM_199191
RefSeq - NM_199192
RefSeq - NM_199193
RefSeq - NM_199194
RefSeq Peptide - NP_954663
RefSeq Peptide - NP_954664
RefSeq Peptide - NP_001316042
RefSeq Peptide - NP_004890
RefSeq Peptide - NP_954661
RefSeq Peptide - NP_954662
RefSeq Peptide - NP_001248769
RefSeq Peptide - NP_001316041
swissprot - Q9NXR7
swissprot - C9J2G0
swissprot - F8W733
swissprot - A0A075B7D2
Ensembl - ENSG00000158019
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 babam2ENSDARG00000038863Danio rerio
 BREENSGALG00000010039Gallus gallus
 Babam2ENSMUSG00000052139Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR010358  BRCA1-A complex subunit BRE
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IMP
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining TAS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0010212 response to ionizing radiation IMP
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0045739 positive regulation of DNA repair IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0070536 protein K63-linked deubiquitination IC
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint IMP
 cellular_componentGO:0000152 nuclear ubiquitin ligase complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0070531 BRCA1-A complex IEA
 cellular_componentGO:0070552 BRISC complex IEA
 molecular_functionGO:0000268 peroxisome targeting sequence binding TAS
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IDA


Pathways (from Reactome)
Pathway description
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000162711 NLRP3 / Q96P20 / NLR family pyrin domain containing 3  / complex
 ENSG00000165660 Q15018 / ABRAXAS2 / abraxas 2, BRISC complex subunit  / complex
 ENSG00000185515 BRCC3 / P46736 / BRCA1/BRCA2-containing complex subunit 3  / complex
 ENSG00000105393 BABAM1 / Q9NWV8 / BRISC and BRCA1 A complex member 1  / complex






 

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contact: otassy@igbmc.fr