ENSG00000158528


Homo sapiens
regulationPPP1R9Abindingproteinactindevelopmentdomainneurondendriticspinefilamentprojectioncellassemblysynapsecytoskeletonpdzsterilealphamotifsuperfamilykinaseactivityfilopodiumpostsynapticsynapticlamellipodiumjunctiongrowthconepointed

Features
Gene ID: ENSG00000158528
  
Biological name :PPP1R9A
  
Synonyms : PPP1R9A / protein phosphatase 1 regulatory subunit 9A / Q9ULJ8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q21.3
Gene start: 94907202
Gene end: 95296415
  
Corresponding Affymetrix probe sets: 221088_s_at (Human Genome U133 Plus 2.0 Array)   228494_at (Human Genome U133 Plus 2.0 Array)   231966_at (Human Genome U133 Plus 2.0 Array)   233985_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000405514
Ensembl peptide - ENSP00000402893
Ensembl peptide - ENSP00000405820
Ensembl peptide - ENSP00000411342
Ensembl peptide - ENSP00000289495
Ensembl peptide - ENSP00000344524
Ensembl peptide - ENSP00000398499
Ensembl peptide - ENSP00000398870
NCBI entrez gene - 55607     See in Manteia.
OMIM - 602468
RefSeq - XM_017012410
RefSeq - XM_017012401
RefSeq - XM_017012402
RefSeq - XM_017012403
RefSeq - XM_017012404
RefSeq - XM_017012405
RefSeq - XM_017012406
RefSeq - XM_017012407
RefSeq - XM_017012408
RefSeq - NM_001166160
RefSeq - NM_001166161
RefSeq - NM_001166162
RefSeq - NM_001166163
RefSeq - NM_017650
RefSeq - XM_011516380
RefSeq - XM_011516381
RefSeq - XM_011516382
RefSeq - XM_011516383
RefSeq - XM_011516389
RefSeq - XM_017012394
RefSeq - XM_017012395
RefSeq - XM_017012396
RefSeq - XM_017012397
RefSeq - XM_017012398
RefSeq - XM_017012399
RefSeq - XM_017012400
RefSeq Peptide - NP_001159635
RefSeq Peptide - NP_001159632
RefSeq Peptide - NP_001159633
RefSeq Peptide - NP_060120
RefSeq Peptide - NP_001159634
swissprot - Q9ULJ8
swissprot - C9J730
swissprot - C9J3G5
Ensembl - ENSG00000158528
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp1r9aENSDARG00000061304Danio rerio
 ENSGALG00000045286Gallus gallus
 ENSGALG00000009686Gallus gallus
 Ppp1r9aENSMUSG00000032827Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPP1R9B / protein phosphatase 1 regulatory subunit 9BENSG0000010881928
AFDN / P55196 / afadin, adherens junction formation factorENSG0000013039617
Q8IZD0 / SAMD14 / sterile alpha motif domain containing 14ENSG000001671009


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001660  Sterile alpha motif domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR029994  Neurabin-1
 IPR036034  PDZ superfamily


Gene Ontology (GO)
cellular component organizationactin filament-based processanatomical structure developmentagingcellular developmental processcell communicationcellular response to stimuluscellular component biogenesisregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsystem processresponse to chemicalestablishment of localizationcellular localizationcellular component organizationactin filament-based processanatomical structure developmentagingcellular developmental processcell communicationcellular response to stimuluscellular component biogenesisregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsystem processresponse to chemicalestablishment of localizationcellular localizationcellular component organizationactin filament-based processanatomical structure developmentagingcellular developmental processcell communicationcellular response to stimuluscellular component biogenesisregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsystem processresponse to chemicalestablishment of localizationcellular localizationcellular component organizationactin filament-based processanatomical structure developmentagingcellular developmental processcell communicationcellular response to stimuluscellular component biogenesisregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsystem processresponse to chemicalestablishment of localizationcellular localizationcellular component organizationactin filament-based processanatomical structure developmentagingcellular developmental processcell communicationcellular response to stimuluscellular component biogenesisregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsystem processresponse to chemicalestablishment of localizationcellular localizationcellular component organizationactin filament-based processanatomical structure developmentagingcellular developmental processcell communicationcellular response to stimuluscellular component biogenesisregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsystem processresponse to chemicalestablishment of localizationcellular localizationcellular component organizationactin filament-based processanatomical structure developmentagingcellular developmental processcell communicationcellular response to stimuluscellular component biogenesisregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsystem processresponse to chemicalestablishment of localizationcellular localizationcellular component organizationactin filament-based processanatomical structure developmentagingcellular developmental processcell communicationcellular response to stimuluscellular component biogenesisregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsystem processresponse to chemicalestablishment of localizationcellular localizationcellular component organizationactin filament-based processanatomical structure developmentagingcellular developmental processcell communicationcellular response to stimuluscellular component biogenesisregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsystem processresponse to chemicalestablishment of localizationcellular localizationcellular component organizationactin filament-based processanatomical structure developmentagingcellular developmental processcell communicationcellular response to stimuluscellular component biogenesisregulation of biological qualitynitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processsystem processresponse to chemicalestablishment of localizationcellular localizationcellulacellular component organizationactin factin filament-based processanatomianatomical structure developmentagingagingcellulacellular developmental processcell cocell communicationcellulacellular response to stimuluscellulacellular component biogenesisregulatregulation of biological qualitynitrogenitrogen compound metabolic processcellulacellular metabolic processprimaryprimary metabolic processregulatregulation of molecular functionorganicorganic substance metabolic processsystem system processresponsresponse to chemicalestabliestablishment of localizationcellulacellular localization
protein bindingprotein-containing complex bindingprotein bindingprotein-containing complex bindingprotein bindingprotein-containing complex bindingprotein bindingprotein-containing complex bindingprotein bindingprotein-containing complex bindingprotein bindingprotein-containing complex bindingprotein bindingprotein-containing complex bindingprotein bindingprotein-containing complex bindingprotein bindingprotein-containing complex bindingprotein bindingprotein-containing complex bindingprotein bindingprotein bindingprotein-containing complex bindingprotein-containing complex binding
cellorganellesynapsecell junctioncellorganellesynapsecell junctioncellorganellesynapsecell junctioncellorganellesynapsecell junctioncellorganellesynapsecell junctioncellorganellesynapsecell junctioncellorganellesynapsecell junctioncellorganellesynapsecell junctioncellorganellesynapsecell junctioncellorganellesynapsecell junctioncellcellorganelleorganellesynapsesynapsecell junctioncell junction
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030833 regulation of actin filament polymerization IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0051489 regulation of filopodium assembly IEA
 biological_processGO:0051497 negative regulation of stress fiber assembly IEA
 biological_processGO:0051823 regulation of synapse structural plasticity IEA
 biological_processGO:0051963 regulation of synapse assembly IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060999 positive regulation of dendritic spine development IEA
 biological_processGO:0061001 regulation of dendritic spine morphogenesis IEA
 biological_processGO:0097237 cellular response to toxic substance IEA
 biological_processGO:1900272 negative regulation of long-term synaptic potentiation IEA
 biological_processGO:1900454 positive regulation of long term synaptic depression IEA
 biological_processGO:1904049 negative regulation of spontaneous neurotransmitter secretion IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044326 dendritic spine neck IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:1990761 growth cone lamellipodium IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008157 protein phosphatase 1 binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0051015 actin filament binding IEA
 molecular_functionGO:0051020 GTPase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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