ENSG00000159788


Homo sapiens
domainRGS12activitysuperfamilyregulationrgssignalgtpasepdztransductionreceptorproteinnuclearcellgolocomotifraf-likeras-bindingptbpiph-likesubdomainubiquitin-liketranscriptiondna-templatedg-proteincoupledsignalingpathwaycatalyticcondensed

Features
Gene ID: ENSG00000159788
  
Biological name :RGS12
  
Synonyms : O14924 / regulator of G protein signaling 12 / RGS12
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: p16.3
Gene start: 3293028
Gene end: 3439913
  
Corresponding Affymetrix probe sets: 1555022_at (Human Genome U133 Plus 2.0 Array)   1555032_at (Human Genome U133 Plus 2.0 Array)   1555033_a_at (Human Genome U133 Plus 2.0 Array)   205823_at (Human Genome U133 Plus 2.0 Array)   209637_s_at (Human Genome U133 Plus 2.0 Array)   209638_x_at (Human Genome U133 Plus 2.0 Array)   209639_s_at (Human Genome U133 Plus 2.0 Array)   214361_s_at (Human Genome U133 Plus 2.0 Array)   214362_at (Human Genome U133 Plus 2.0 Array)   242079_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000424251
Ensembl peptide - ENSP00000372238
Ensembl peptide - ENSP00000493646
Ensembl peptide - ENSP00000338509
Ensembl peptide - ENSP00000339381
Ensembl peptide - ENSP00000342133
NCBI entrez gene - 6002     See in Manteia.
OMIM - 602512
RefSeq - XM_017008534
RefSeq - NM_002926
RefSeq - NM_198227
RefSeq - NM_198229
RefSeq - XM_011513543
RefSeq - XM_017008529
RefSeq - XM_017008531
RefSeq - XM_017008532
RefSeq - XM_017008533
RefSeq - XM_006713905
RefSeq - XM_006713906
RefSeq - XM_006713907
RefSeq Peptide - NP_002917
RefSeq Peptide - NP_937870
RefSeq Peptide - NP_937872
swissprot - O14924
swissprot - E9PBG5
Ensembl - ENSG00000159788
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgs12aENSDARG00000009610Danio rerio
 rgs12bENSDARG00000036774Danio rerio
 RGS12ENSGALG00000015626Gallus gallus
 Rgs12ENSMUSG00000029101Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RGS14 / O43566 / regulator of G protein signaling 14ENSG0000016922017
RGS9 / O75916 / regulator of G protein signaling 9ENSG0000010837010
RGS11 / O94810 / regulator of G protein signaling 11ENSG000000763449
RGS6 / P49758 / regulator of G protein signaling 6ENSG000001827328
RGS7 / P49802 / regulator of G protein signaling 7ENSG000001829018
RGS10 / O43665 / regulator of G protein signaling 10ENSG000001489086


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR003109  GoLoco motif
 IPR003116  Raf-like Ras-binding
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR029071  Ubiquitin-like domain superfamily
 IPR036034  PDZ superfamily
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of molecular functionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of molecular functionnitrogen compoundnitrogen compound metabolic processbiosynthetic procbiosynthetic processcellular metabolicellular metabolic processprimary metabolicprimary metabolic processorganic substanceorganic substance metabolic processcell communicatiocell communicationcellular responsecellular response to stimulusregulation of molregulation of molecular function
enzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityenzyme regulator activityprotein bindingprotein binding
cellorganellemembrane-enclosed lumenmembranecell junctionsynapsecellorganellemembrane-enclosed lumenmembranecell junctionsynapsecellorganellemembrane-enclosed lumenmembranecell junctionsynapsecellorganellemembrane-enclosed lumenmembranecell junctionsynapsecellorganellemembrane-enclosed lumenmembranecell junctionsynapsecellorganellemembrane-enclosed lumenmembranecell junctionsynapsecellorganellemembrane-enclosed lumenmembranecell junctionsynapsecellorganellemembrane-enclosed lumenmembranecell junctionsynapsecellorganellemembrane-enclosed lumenmembranecell junctionsynapsecellorganellemembrane-enclosed lumenmembranecell junctionsynapsecellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenmembranemembranecell junctioncell junctionsynapsesynapse
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 cellular_componentGO:0000794 condensed nuclear chromosome TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse ISS
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030695 GTPase regulator activity IDA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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