ENSG00000160949


Homo sapiens
domainTONSLrepeatankyrinsuperfamilyrepeat-containingdnareplicationtranscriptioncomplexleucine-richtetratricopeptiderepairforkfactornuclearbindingtetratricopeptide-likehelicaldouble-strandbreakviahomologousrecombinationcellularresponsedamagestimulusprocessingcytoplasmicsequestering

Features
Gene ID: ENSG00000160949
  
Biological name :TONSL
  
Synonyms : Q96HA7 / TONSL / tonsoku like, DNA repair protein
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q24.3
Gene start: 144428775
Gene end: 144444444
  
Corresponding Affymetrix probe sets: 1558329_at (Human Genome U133 Plus 2.0 Array)   1558330_x_at (Human Genome U133 Plus 2.0 Array)   207137_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000484162
Ensembl peptide - ENSP00000386239
NCBI entrez gene - 4796     See in Manteia.
OMIM - 604546
RefSeq - XM_011517050
RefSeq - NM_013432
RefSeq - XM_011517048
RefSeq - XM_011517049
RefSeq Peptide - NP_038460
swissprot - A0A087X1F6
swissprot - Q96HA7
Ensembl - ENSG00000160949
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tonslENSDARG00000071294Danio rerio
 TonslENSMUSG00000059323Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8N7Z5 / ANKRD31 / ankyrin repeat domain 31ENSG0000014570013
Q6UB99 / ANKRD11 / ankyrin repeat domain 11ENSG0000016752211
BCOR / Q6W2J9 / BCL6 corepressorENSG0000018333711
Q6UB98 / ANKRD12 / ankyrin repeat domain 12ENSG0000010174510
BCORL1 / Q5H9F3 / BCL6 corepressor like 1ENSG000000851859
BARD1 / Q99728 / BRCA1 associated RING domain 1ENSG000001383769
SLF1 / Q9BQI6 / SMC5-SMC6 complex localization factor 1ENSG000001333028


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR002110  Ankyrin repeat
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusbiosynthetic processmacromolecule localizationregulation of biological qualityregulation of molecular functionnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusbiosynthetic processmacromolecule localizationregulation of biological qualityregulation of molecular functionnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusbiosynthetic processmacromolecule localizationregulation of biological qualityregulation of molecular functionnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusbiosynthetic processmacromolecule localizationregulation of biological qualityregulation of molecular functionnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusbiosynthetic processmacromolecule localizationregulation of biological qualityregulation of molecular functionnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusbiosynthetic processmacromolecule localizationregulation of biological qualityregulation of molecular functionnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusbiosynthetic processmacromolecule localizationregulation of biological qualityregulation of molecular functionnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusbiosynthetic processmacromolecule localizationregulation of biological qualityregulation of molecular functionnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusbiosynthetic processmacromolecule localizationregulation of biological qualityregulation of molecular functionnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimulusbiosynthetic processmacromolecule localizationregulation of biological qualityregulation of molecular functionnitrogen componitrogen compound metabolic processresponse to stresponse to stresscellular metabcellular metabolic processprimary metaboprimary metabolic processorganic substaorganic substance metabolic processcellular respocellular response to stimulusbiosynthetic pbiosynthetic processmacromolecule macromolecule localizationregulation of regulation of biological qualityregulation of regulation of molecular function
transcription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activityprotein bindingtranscription coregulator activitytranscription coregulator activityprotein bindingprotein binding
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0031297 replication fork processing IMP
 biological_processGO:0042994 cytoplasmic sequestering of transcription factor TAS
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005662 DNA replication factor A complex IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0035101 FACT complex IDA
 cellular_componentGO:0042555 MCM complex IDA
 cellular_componentGO:0043596 nuclear replication fork IDA
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042393 histone binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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