ENSG00000163918


Homo sapiens

Features
Gene ID: ENSG00000163918
  
Biological name :RFC4
  
Synonyms : P35249 / replication factor C subunit 4 / RFC4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q27.3
Gene start: 186789880
Gene end: 186807058
  
Corresponding Affymetrix probe sets: 204023_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000394870
Ensembl peptide - ENSP00000399314
Ensembl peptide - ENSP00000415099
Ensembl peptide - ENSP00000413065
Ensembl peptide - ENSP00000411300
Ensembl peptide - ENSP00000407982
Ensembl peptide - ENSP00000401429
Ensembl peptide - ENSP00000399769
Ensembl peptide - ENSP00000296273
Ensembl peptide - ENSP00000376272
NCBI entrez gene - 5984     See in Manteia.
OMIM - 102577
RefSeq - NM_181573
RefSeq - NM_002916
RefSeq Peptide - NP_002907
RefSeq Peptide - NP_853551
swissprot - C9JGY5
swissprot - C9J8M3
swissprot - F8WE44
swissprot - H7C1P0
swissprot - C9JZI1
swissprot - P35249
swissprot - C9JXZ7
swissprot - C9JW34
swissprot - C9JTT7
Ensembl - ENSG00000163918
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rfc4ENSDARG00000042458Danio rerio
 RFC4ENSGALG00000008703Gallus gallus
 Rfc4ENSMUSG00000022881Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR008921  DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
 IPR013748  Replication factor C, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006271 DNA strand elongation involved in DNA replication TAS
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006296 nucleotide-excision repair, DNA incision, 5"-to lesion TAS
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling TAS
 biological_processGO:0019985 translesion synthesis TAS
 biological_processGO:0032201 telomere maintenance via semi-conservative replication TAS
 biological_processGO:0033683 nucleotide-excision repair, DNA incision TAS
 biological_processGO:0042276 error-prone translesion synthesis TAS
 biological_processGO:0042769 DNA damage response, detection of DNA damage TAS
 biological_processGO:0070987 error-free translesion synthesis TAS
 biological_processGO:1900264 positive regulation of DNA-directed DNA polymerase activity IDA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005663 DNA replication factor C complex IDA
 cellular_componentGO:0031390 Ctf18 RFC-like complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003689 DNA clamp loader activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0043142 single-stranded DNA-dependent ATPase activity IDA


Pathways (from Reactome)
Pathway description
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Polymerase switching on the C-strand of the telomere
Activation of ATR in response to replication stress
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Regulation of TP53 Activity through Phosphorylation
Polymerase switching
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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