ENSG00000164825


Homo sapiens
responseDEFB1immunedefensebacteriumsignalingantimicrobialhumoralextracellularbindingbetainnatereceptorspermmembraneproteindefensinsdefensintypemucosachemotaxisg-proteincoupledpathwayantibacterialcamp-mediatedcalcium-mediatedusingintracellularcalciumsource

Features
Gene ID: ENSG00000164825
  
Biological name :DEFB1
  
Synonyms : DEFB1 / defensin beta 1 / P60022
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p23.1
Gene start: 6870575
Gene end: 6878022
  
Corresponding Affymetrix probe sets: 210397_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000297439
NCBI entrez gene - 1672     See in Manteia.
OMIM - 602056
RefSeq - NM_005218
RefSeq Peptide - NP_005209
swissprot - P60022
Ensembl - ENSG00000164825
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Defb1ENSMUSG00000044748Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001855  Beta defensin type


Gene Ontology (GO)
response to stressimmune responseresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to biotic stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse to stressimmune responseresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to biotic stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse to stressimmune responseresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to biotic stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse to stressimmune responseresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to biotic stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse to stressimmune responseresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to biotic stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse to stressimmune responseresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to biotic stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse to stressimmune responseresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to biotic stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse to stressimmune responseresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to biotic stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse to stressimmune responseresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to biotic stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse to stressimmune responseresponse to external stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to biotic stimuluslocalization of cellmovement of cell or subcellular componentanatomical structure developmentcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse tresponse to stressimmune resimmune responseresponse tresponse to external stimulusresponse tresponse to chemicalcell commucell communicationcellular rcellular response to stimulusresponse tresponse to biotic stimuluslocalizatilocalization of cellmovement omovement of cell or subcellular componentanatomicalanatomical structure developmentcellular dcellular developmental processmulticellumulticellular organism reproductiondevelopmendevelopmental maturation
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
extracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regioncellorganellemembrane-enclosed lumenmembraneextracellular regionextracellular regioncellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0002227 innate immune response in mucosa IDA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0009617 response to bacterium ISS
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0019731 antibacterial humoral response IDA
 biological_processGO:0019933 cAMP-mediated signaling IDA
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source IDA
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0045087 innate immune response NAS
 biological_processGO:0050829 defense response to Gram-negative bacterium IMP
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0060474 positive regulation of flagellated sperm motility involved in capacitation IMP
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097225 sperm midpiece IDA
 cellular_componentGO:1990742 microvesicle IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031731 CCR6 chemokine receptor binding IDA
 molecular_functionGO:0042802 identical protein binding IDA


Pathways (from Reactome)
Pathway description
Beta defensins
Defensins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112486 CCR6 / P51684 / C-C motif chemokine receptor 6  / complex / reaction






 

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