ENSG00000171711


Homo sapiens
responseDEFB4Adefensebetaantimicrobialbacteriumdefensinimmunereceptorhumoralextracellularbindingdefensinstypealphachemotaxisg-proteincoupledsignalingpathwaykillingcellsorganismgram-negativegram-positivemediatedpeptideregionspaceintracellulargolgi

Features
Gene ID: ENSG00000171711
  
Biological name :DEFB4A
  
Synonyms : DEFB4A / defensin beta 4A / O15263
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p23.1
Gene start: 7894629
Gene end: 7896711
  
Corresponding Affymetrix probe sets: 207356_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000303532
NCBI entrez gene - 1673     See in Manteia.
OMIM - 602215
RefSeq - NM_004942
RefSeq Peptide - NP_004933
swissprot - O15263
Ensembl - ENSG00000171711
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DEFB4B / O15263 / defensin beta 4BENSG00000177257100


Protein motifs (from Interpro)
Interpro ID Name
 IPR001855  Beta defensin type
 IPR006080  Beta/alpha defensin


Gene Ontology (GO)
response to external stimulusresponse to chemicalresponse to stressimmune responsecell communicationcellular response to stimulusresponse to biotic stimulusinterspecies interaction between organismsresponse to external stimulusresponse to chemicalresponse to stressimmune responsecell communicationcellular response to stimulusresponse to biotic stimulusinterspecies interaction between organismsresponse to external stimulusresponse to chemicalresponse to stressimmune responsecell communicationcellular response to stimulusresponse to biotic stimulusinterspecies interaction between organismsresponse to external stimulusresponse to chemicalresponse to stressimmune responsecell communicationcellular response to stimulusresponse to biotic stimulusinterspecies interaction between organismsresponse to external stimulusresponse to chemicalresponse to stressimmune responsecell communicationcellular response to stimulusresponse to biotic stimulusinterspecies interaction between organismsresponse to external stimulusresponse to chemicalresponse to stressimmune responsecell communicationcellular response to stimulusresponse to biotic stimulusinterspecies interaction between organismsresponse to external stimulusresponse to chemicalresponse to stressimmune responsecell communicationcellular response to stimulusresponse to biotic stimulusinterspecies interaction between organismsresponse to external stimulusresponse to chemicalresponse to stressimmune responsecell communicationcellular response to stimulusresponse to biotic stimulusinterspecies interaction between organismsresponse to external stimulusresponse to chemicalresponse to stressimmune responsecell communicationcellular response to stimulusresponse to biotic stimulusinterspecies interaction between organismsresponse to external stimulusresponse to chemicalresponse to stressimmune responsecell communicationcellular response to stimulusresponse to biotic stimulusinterspecies interaction between organismsresponse to exterresponse to external stimulusresponse to chemiresponse to chemicalresponse to stresresponse to stressimmune responseimmune responsecell communicatiocell communicationcellular responsecellular response to stimulusresponse to biotiresponse to biotic stimulusinterspecies inteinterspecies interaction between organisms
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
extracellular regioncellorganellemembrane-enclosed lumenextracellular regioncellorganellemembrane-enclosed lumenextracellular regioncellorganellemembrane-enclosed lumenextracellular regioncellorganellemembrane-enclosed lumenextracellular regioncellorganellemembrane-enclosed lumenextracellular regioncellorganellemembrane-enclosed lumenextracellular regioncellorganellemembrane-enclosed lumenextracellular regioncellorganellemembrane-enclosed lumenextracellular regioncellorganellemembrane-enclosed lumenextracellular regioncellorganellemembrane-enclosed lumenextracellular regionextracellular regioncellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumen
TypeGO IDTermEv.Code
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0031640 killing of cells of other organism IMP
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0050829 defense response to Gram-negative bacterium IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium IDA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005796 Golgi lumen TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031731 CCR6 chemokine receptor binding IDA


Pathways (from Reactome)
Pathway description
Beta defensins
Defensins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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