ENSG00000173020


Homo sapiens

Features
Gene ID: ENSG00000173020
  
Biological name :GRK2
  
Synonyms : G protein-coupled receptor kinase 2 / GRK2 / P25098
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.2
Gene start: 67266410
Gene end: 67286556
  
Corresponding Affymetrix probe sets: 201401_s_at (Human Genome U133 Plus 2.0 Array)   201402_at (Human Genome U133 Plus 2.0 Array)   38447_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000312262
Ensembl peptide - ENSP00000434126
NCBI entrez gene - 156     See in Manteia.
OMIM - 109635
RefSeq - NM_001619
RefSeq - XM_011544773
RefSeq Peptide - NP_001610
swissprot - E9PRV7
swissprot - A0A0S2Z392
swissprot - P25098
Ensembl - ENSG00000173020
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Grk2ENSMUSG00000024858Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRK3 / P35626 / G protein-coupled receptor kinase 3ENSG0000010007784
GRK6 / P43250 / G protein-coupled receptor kinase 6ENSG0000019805530
GRK5 / P34947 / G protein-coupled receptor kinase 5ENSG0000019887329
GRK4 / P32298 / G protein-coupled receptor kinase 4ENSG0000012538828
GRK1 / Q15835 / G protein-coupled receptor kinase 1ENSG0000018597427
GRK7 / Q8WTQ7 / G protein-coupled receptor kinase 7ENSG0000011412424


Protein motifs (from Interpro)
Interpro ID Name
 IPR000239  GPCR kinase
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001849  Pleckstrin homology domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR016137  RGS domain
 IPR017441  Protein kinase, ATP binding site
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002026 regulation of the force of heart contraction IEA
 biological_processGO:0002029 desensitization of G-protein coupled receptor protein signaling pathway ISS
 biological_processGO:0003108 negative regulation of the force of heart contraction by chemical signal IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007213 G-protein coupled acetylcholine receptor signaling pathway ISS
 biological_processGO:0007217 tachykinin receptor signaling pathway IDA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation ISS
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0019079 viral genome replication IMP
 biological_processGO:0031623 receptor internalization IDA
 biological_processGO:0033605 positive regulation of catecholamine secretion ISS
 biological_processGO:0045988 negative regulation of striated muscle contraction IMP
 biological_processGO:0046718 viral entry into host cell IMP
 biological_processGO:0060048 cardiac muscle contraction IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005929 cilium TAS
 cellular_componentGO:0016020 membrane ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004703 G-protein coupled receptor kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031694 alpha-2A adrenergic receptor binding ISS
 molecular_functionGO:0031755 Edg-2 lysophosphatidic acid receptor binding IDA
 molecular_functionGO:0047696 beta-adrenergic receptor kinase activity TAS


Pathways (from Reactome)
Pathway description
Calmodulin induced events
G alpha (q) signalling events
G alpha (s) signalling events
Activation of SMO
Cargo recognition for clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088256 GNA11 / P29992 / G protein subunit alpha 11  / complex / reaction
 ENSG00000128602 SMO / Q99835 / smoothened, frizzled class receptor  / complex / reaction
 ENSG00000126583 PRKCG / P05129 / protein kinase C gamma  / reaction
 ENSG00000060558 GNA15 / P30679 / G protein subunit alpha 15  / complex / reaction
 ENSG00000113712 P48729 / CSNK1A1 / casein kinase 1 alpha 1  / complex / reaction
 ENSG00000156052 GNAQ / P50148 / G protein subunit alpha q  / complex / reaction
 ENSG00000126895 AVPR2 / P30518 / arginine vasopressin receptor 2  / reaction
 ENSG00000156049 GNA14 / O95837 / G protein subunit alpha 14  / reaction / complex
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / complex / reaction
 ENSG00000101200 AVP / P01185 / arginine vasopressin  / reaction
 ENSG00000169252 ADRB2 / P07550 / adrenoceptor beta 2  / complex / reaction
 ENSG00000154229 PRKCA / P17252 / protein kinase C alpha  / reaction
 ENSG00000163932 PRKCD / Q05655 / protein kinase C delta  / reaction






 

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