ENSG00000173157


Homo sapiens

Features
Gene ID: ENSG00000173157
  
Biological name :ADAMTS20
  
Synonyms : ADAM metallopeptidase with thrombospondin type 1 motif 20 / ADAMTS20 / P59510
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q12
Gene start: 43353866
Gene end: 43551921
  
Corresponding Affymetrix probe sets: 1553409_at (Human Genome U133 Plus 2.0 Array)   220717_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000448341
Ensembl peptide - ENSP00000374071
Ensembl peptide - ENSP00000378911
Ensembl peptide - ENSP00000447427
NCBI entrez gene - 80070     See in Manteia.
OMIM - 611681
RefSeq - XM_017019979
RefSeq - NM_025003
RefSeq - XM_011538754
RefSeq Peptide - NP_079279
swissprot - E9PBD5
swissprot - P59510
swissprot - G3V1X8
swissprot - H0YHN3
Ensembl - ENSG00000173157
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ADAMTS20ENSGALG00000009572Gallus gallus
 P59511ENSMUSG00000022449Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9P2N4 / ADAMTS9 / ADAM metallopeptidase with thrombospondin type 1 motif 9ENSG0000016363851
Q8TE58 / ADAMTS15 / ADAM metallopeptidase with thrombospondin type 1 motif 15ENSG0000016610620
Q9UHI8 / ADAMTS1 / ADAM metallopeptidase with thrombospondin type 1 motif 1ENSG0000015473419
Q9UP79 / ADAMTS8 / ADAM metallopeptidase with thrombospondin type 1 motif 8ENSG0000013491718
Q76LX8 / ADAMTS13 / ADAM metallopeptidase with thrombospondin type 1 motif 13ENSG0000016032318
P82987 / ADAMTSL3 / ADAMTS like 3ENSG0000015621817
Q9UNA0 / ADAMTS5 / ADAM metallopeptidase with thrombospondin type 1 motif 5ENSG0000015473616
O75173 / ADAMTS4 / ADAM metallopeptidase with thrombospondin type 1 motif 4ENSG0000015885916
Q8N6G6 / ADAMTSL1 / ADAMTS like 1ENSG0000017803116
Q86TH1 / ADAMTSL2 / ADAMTS like 2ENSG0000019785913
PAPLN / O95428 / papilin, proteoglycan like sulfated glycoproteinENSG0000010076712
Q6UY14 / ADAMTSL4 / ADAMTS like 4ENSG0000014338212
THSD4 / Q6ZMP0 / thrombospondin type 1 domain containing 4ENSG0000018772012


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR010294  ADAM-TS Spacer 1
 IPR012314  Peptidase M12B, GON-ADAMTSs
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045636 positive regulation of melanocyte differentiation IEA
 biological_processGO:0048070 regulation of developmental pigmentation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix TAS
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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