ENSG00000174576


Homo sapiens

Features
Gene ID: ENSG00000174576
  
Biological name :NPAS4
  
Synonyms : neuronal PAS domain protein 4 / NPAS4 / Q8IUM7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.2
Gene start: 66421004
Gene end: 66426707
  
Corresponding Affymetrix probe sets: 1554299_at (Human Genome U133 Plus 2.0 Array)   240794_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000311196
Ensembl peptide - ENSP00000433135
Ensembl peptide - ENSP00000492526
NCBI entrez gene - 266743     See in Manteia.
OMIM - 608554
RefSeq - XM_017017539
RefSeq - NM_001318804
RefSeq - NM_178864
RefSeq - XM_017017537
RefSeq Peptide - NP_001305733
RefSeq Peptide - NP_849195
swissprot - Q8IUM7
Ensembl - ENSG00000174576
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR388166.1ENSDARG00000087753Danio rerio
 npas4aENSDARG00000055752Danio rerio
 ENSGALG00000041074Gallus gallus
 Npas4ENSMUSG00000045903Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013655  PAS fold-3
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007612 learning ISS
 biological_processGO:0007614 short-term memory ISS
 biological_processGO:0007616 long-term memory ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic ISS
 biological_processGO:0035176 social behavior ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048167 regulation of synaptic plasticity ISS
 biological_processGO:0060079 excitatory postsynaptic potential ISS
 biological_processGO:0060080 inhibitory postsynaptic potential ISS
 biological_processGO:0071386 cellular response to corticosterone stimulus IEA
 biological_processGO:1904862 inhibitory synapse assembly ISS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001012 RNA polymerase II regulatory region DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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