ENSG00000177465


Homo sapiens

Features
Gene ID: ENSG00000177465
  
Biological name :ACOT4
  
Synonyms : ACOT4 / acyl-CoA thioesterase 4 / Q8N9L9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q24.3
Gene start: 73591706
Gene end: 73596496
  
Corresponding Affymetrix probe sets: 229534_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000323071
NCBI entrez gene - 122970     See in Manteia.
OMIM - 614314
RefSeq - NM_152331
RefSeq Peptide - NP_689544
swissprot - Q8N9L9
Ensembl - ENSG00000177465
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acot20ENSDARG00000042510Danio rerio
 acot21ENSDARG00000042513Danio rerio
 acot22ENSDARG00000058945Danio rerio
 ENSGALG00000009292Gallus gallus
 Acot4ENSMUSG00000052392Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACOT2 / P49753 / acyl-CoA thioesterase 2ENSG0000011967370
ACOT1 / Q86TX2 / acyl-CoA thioesterase 1ENSG0000018422770
BAAT / Q14032 / bile acid-CoA:amino acid N-acyltransferaseENSG0000013688144
ACOT6 / Q3I5F7 / acyl-CoA thioesterase 6ENSG0000020566927


Protein motifs (from Interpro)
Interpro ID Name
 IPR006862  Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
 IPR014940  BAAT/Acyl-CoA thioester hydrolase C-terminal
 IPR016662  Acyl-CoA thioesterase, long chain
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000038 very long-chain fatty acid metabolic process IDA
 biological_processGO:0001676 long-chain fatty acid metabolic process IDA
 biological_processGO:0006104 succinyl-CoA metabolic process IDA
 biological_processGO:0006637 acyl-CoA metabolic process IDA
 biological_processGO:0032788 saturated monocarboxylic acid metabolic process IDA
 biological_processGO:0032789 unsaturated monocarboxylic acid metabolic process IDA
 biological_processGO:0043648 dicarboxylic acid metabolic process IDA
 biological_processGO:0043649 dicarboxylic acid catabolic process IDA
 biological_processGO:0046459 short-chain fatty acid metabolic process IDA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005782 peroxisomal matrix TAS
 molecular_functionGO:0004778 succinyl-CoA hydrolase activity IDA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0016290 palmitoyl-CoA hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016790 thiolester hydrolase activity IEA
 molecular_functionGO:0047617 acyl-CoA hydrolase activity IEA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA
 molecular_functionGO:0102991 myristoyl-CoA hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Beta-oxidation of very long chain fatty acids
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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