ENSG00000181656


Homo sapiens

Features
Gene ID: ENSG00000181656
  
Biological name :GPR88
  
Synonyms : GPR88 / G protein-coupled receptor 88 / Q9GZN0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p21.2
Gene start: 100538137
Gene end: 100542018
  
Corresponding Affymetrix probe sets: 220313_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000314223
NCBI entrez gene - 54112     See in Manteia.
OMIM - 607468
RefSeq - NM_022049
RefSeq Peptide - NP_071332
swissprot - Q9GZN0
Ensembl - ENSG00000181656
  
Related genetic diseases (OMIM): 616939 - ?Chorea, childhood-onset, with psychomotor retardation, 616939
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GPR88ENSGALG00000005252Gallus gallus
 Gpr88ENSMUSG00000068696Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway NAS
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0007631 feeding behavior IBA
 biological_processGO:0019228 neuronal action potential IEA
 biological_processGO:0050885 neuromuscular process controlling balance IEA
 biological_processGO:0061743 motor learning IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0001249 Mental retardation 
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 HP:0001263 Developmental retardation "A delay in the achievement of motor or mental milestones manifested prior to age 18 and generally associated with lifelong mental and/or physical impairments." [HPO:curators]
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 HP:0002072 Chorea "Chorea (Greek for dance ) refers to widespread arrhythmic involuntary movements of a forcible, jerky and restless fashion." [HPO:curators]
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 HP:0002457 Abnormal head movements 
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 HP:0002465 Poor speech 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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