ENSG00000181690


Homo sapiens

Features
Gene ID: ENSG00000181690
  
Biological name :PLAG1
  
Synonyms : PLAG1 / PLAG1 zinc finger / Q6DJT9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q12.1
Gene start: 56160904
Gene end: 56211324
  
Corresponding Affymetrix probe sets: 205372_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000416537
Ensembl peptide - ENSP00000325546
Ensembl peptide - ENSP00000404067
NCBI entrez gene - 5324     See in Manteia.
OMIM - 603026
RefSeq - XM_017013577
RefSeq - NM_001114634
RefSeq - NM_001114635
RefSeq - NM_002655
RefSeq - XM_011517544
RefSeq - XM_017013576
RefSeq Peptide - NP_002646
RefSeq Peptide - NP_001108106
RefSeq Peptide - NP_001108107
swissprot - Q6DJT9
swissprot - A0A024R7Z0
Ensembl - ENSG00000181690
  
Related genetic diseases (OMIM): 181030 - Adenomas, salivary gland pleomorphic, somatic, 181030

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plag1ENSDARG00000051926Danio rerio
 PLAG1ENSGALG00000015407Gallus gallus
 Plag1ENSMUSG00000003282Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLAGL2 / Q9UPG8 / PLAG1 like zinc finger 2ENSG0000012600344
PLAGL1 / Q9UM63 / PLAG1 like zinc finger 1ENSG0000011849541


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR027765  Zinc finger protein PLAG1
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006915 apoptotic process IBA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0022612 gland morphogenesis IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0035265 organ growth IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0060252 positive regulation of glial cell proliferation IEA
 biological_processGO:0060736 prostate gland growth IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0001428 Somatic mutation 
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 HP:0100684 Salivary gland neoplasia 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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