ENSG00000182158


Homo sapiens

Features
Gene ID: ENSG00000182158
  
Biological name :CREB3L2
  
Synonyms : cAMP responsive element binding protein 3 like 2 / CREB3L2 / Q70SY1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q33
Gene start: 137874979
Gene end: 138002067
  
Corresponding Affymetrix probe sets: 212345_s_at (Human Genome U133 Plus 2.0 Array)   228759_at (Human Genome U133 Plus 2.0 Array)   237819_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000402889
Ensembl peptide - ENSP00000403550
Ensembl peptide - ENSP00000478809
Ensembl peptide - ENSP00000478432
Ensembl peptide - ENSP00000410314
Ensembl peptide - ENSP00000329140
Ensembl peptide - ENSP00000388917
NCBI entrez gene - 64764     See in Manteia.
OMIM - 608834
RefSeq - NM_194071
RefSeq - XM_017012541
RefSeq - XM_017012540
RefSeq - XM_005250541
RefSeq - NM_001253775
RefSeq - NM_001318246
RefSeq Peptide - NP_001240704
RefSeq Peptide - NP_001305175
RefSeq Peptide - NP_919047
swissprot - A0A087WUP1
swissprot - Q70SY1
swissprot - H7C1W8
swissprot - C9JPH0
swissprot - A0A087WU77
Ensembl - ENSG00000182158
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A1L224ENSDARG00000063563Danio rerio
 CREB3L2ENSGALG00000012877Gallus gallus
 Q8BH52ENSMUSG00000038648Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q96BA8 / CREB3L1 / cAMP responsive element binding protein 3 like 1ENSG0000015761343
Q68CJ9 / CREB3L3 / cAMP responsive element binding protein 3 like 3ENSG0000006056623
Q8TEY5 / CREB3L4 / cAMP responsive element binding protein 3 like 4ENSG0000014357819
CREB3 / O43889 / cAMP responsive element binding protein 3ENSG0000010717518


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029804  cAMP-responsive element-binding protein 3-like protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002062 chondrocyte differentiation ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IEA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051216 cartilage development ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0035497 cAMP response element binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IMP


Pathways (from Reactome)
Pathway description
CREB3 factors activate genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000140943 MBTPS1 / Q14703 / membrane bound transcription factor peptidase, site 1  / reaction
 ENSG00000012174 MBTPS2 / O43462 / membrane bound transcription factor peptidase, site 2  / reaction






 

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