ENSG00000186866


Homo sapiens
activityPOFUT2proteinregulationmetabolicprocessfucosylationendoplasmicreticulumtransferasegdp-fucoseo-fucosyltransferasemesodermformationcarbohydratefucoseglycosylationgeneexpressionepithelialmesenchymaltransitiono-linkedsecretionmembranegolgiapparatusfucosyltransferasetransferringglycosylgroups

Features
Gene ID: ENSG00000186866
  
Biological name :POFUT2
  
Synonyms : POFUT2 / protein O-fucosyltransferase 2 / Q9Y2G5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: -1
Band: q22.3
Gene start: 45263928
Gene end: 45287898
  
Corresponding Affymetrix probe sets: 1555546_a_at (Human Genome U133 Plus 2.0 Array)   207448_at (Human Genome U133 Plus 2.0 Array)   207449_s_at (Human Genome U133 Plus 2.0 Array)   209578_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478168
Ensembl peptide - ENSP00000407635
Ensembl peptide - ENSP00000482216
Ensembl peptide - ENSP00000329682
Ensembl peptide - ENSP00000335427
Ensembl peptide - ENSP00000339613
NCBI entrez gene - 23275     See in Manteia.
OMIM - 610249
RefSeq - XM_017028307
RefSeq - XM_011529505
RefSeq - XM_011529506
RefSeq - XM_011529507
RefSeq - XM_011529510
RefSeq - XM_011529513
RefSeq - XM_017028306
RefSeq - NM_015227
RefSeq - NM_133635
RefSeq - XM_006723981
RefSeq - XM_011529504
RefSeq Peptide - NP_056042
RefSeq Peptide - NP_598368
swissprot - H7C2T5
swissprot - S6FW71
swissprot - A0A0C4DGX7
swissprot - Q9Y2G5
Ensembl - ENSG00000186866
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pofut2ENSDARG00000045175Danio rerio
 POFUT2ENSGALG00000006141Gallus gallus
 Pofut2ENSMUSG00000020260Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019378  GDP-fucose protein O-fucosyltransferase


Gene Ontology (GO)
anatomical structure developmentprimary metabolic processorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processglycosylationcellular developmental processestablishment of localizationanatomical structure developmentprimary metabolic processorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processglycosylationcellular developmental processestablishment of localizationanatomical structure developmentprimary metabolic processorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processglycosylationcellular developmental processestablishment of localizationanatomical structure developmentprimary metabolic processorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processglycosylationcellular developmental processestablishment of localizationanatomical structure developmentprimary metabolic processorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processglycosylationcellular developmental processestablishment of localizationanatomical structure developmentprimary metabolic processorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processglycosylationcellular developmental processestablishment of localizationanatomical structure developmentprimary metabolic processorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processglycosylationcellular developmental processestablishment of localizationanatomical structure developmentprimary metabolic processorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processglycosylationcellular developmental processestablishment of localizationanatomical structure developmentprimary metabolic processorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processglycosylationcellular developmental processestablishment of localizationanatomical structure developmentprimary metabolic processorganic substance metabolic processsmall molecule metabolic processnitrogen compound metabolic processbiosynthetic processcellular metabolic processglycosylationcellular developmental processestablishment of localizationanatomical stranatomical structure developmentprimary metaboprimary metabolic processorganic substaorganic substance metabolic processsmall moleculesmall molecule metabolic processnitrogen componitrogen compound metabolic processbiosynthetic pbiosynthetic processcellular metabcellular metabolic processglycosylationglycosylationcellular develcellular developmental processestablishment establishment of localization
transferase activitycatalytic activity, acting on a proteintransferase activitycatalytic activity, acting on a proteintransferase activitycatalytic activity, acting on a proteintransferase activitycatalytic activity, acting on a proteintransferase activitycatalytic activity, acting on a proteintransferase activitycatalytic activity, acting on a proteintransferase activitycatalytic activity, acting on a proteintransferase activitycatalytic activity, acting on a proteintransferase activitycatalytic activity, acting on a proteintransferase activitycatalytic activity, acting on a proteintransferase activitytransferase activitycatalytic activity, acting on a proteincatalytic activity, acting on a protein
cellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellcellorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0001707 mesoderm formation IEA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006004 fucose metabolic process IEA
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010717 regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0036065 fucosylation IEA
 biological_processGO:0036066 protein O-linked fucosylation TAS
 biological_processGO:0051046 regulation of secretion IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 molecular_functionGO:0008417 fucosyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0046922 peptide-O-fucosyltransferase activity TAS


Pathways (from Reactome)
Pathway description
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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