ENSG00000187446


Homo sapiens

Features
Gene ID: ENSG00000187446
  
Biological name :CHP1
  
Synonyms : calcineurin like EF-hand protein 1 / CHP1 / Q99653
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q15.1
Gene start: 41230839
Gene end: 41281890
  
Corresponding Affymetrix probe sets: 207993_s_at (Human Genome U133 Plus 2.0 Array)   214665_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453392
Ensembl peptide - ENSP00000453375
Ensembl peptide - ENSP00000454007
Ensembl peptide - ENSP00000335632
Ensembl peptide - ENSP00000440490
Ensembl peptide - ENSP00000452772
NCBI entrez gene - 11261     See in Manteia.
OMIM - 606988
RefSeq - XM_017021879
RefSeq - NM_007236
RefSeq Peptide - NP_009167
swissprot - H0YLX1
swissprot - H0YLY7
swissprot - H0YNG9
swissprot - A0A024R9M9
swissprot - Q99653
swissprot - H0YKE7
swissprot - F5GX29
Ensembl - ENSG00000187446
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chp1ENSDARG00000052859Danio rerio
 CHP1ENSGALG00000008569Gallus gallus
 Chp1ENSMUSG00000014077Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CHP2 / O43745 / calcineurin like EF-hand protein 2ENSG0000016686961
P63098 / PPP3R1 / protein phosphatase 3 regulatory subunit B, alphaENSG0000022182335
TESC / Q96BS2 / tescalcinENSG0000008899233
PPP3R2 / Q96LZ3 / protein phosphatase 3 regulatory subunit B, betaENSG0000018838633
AC017083.3ENSG0000027339833


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001578 microtubule bundle formation ISS
 biological_processGO:0001933 negative regulation of protein phosphorylation ISS
 biological_processGO:0006469 negative regulation of protein kinase activity ISS
 biological_processGO:0006611 protein export from nucleus ISS
 biological_processGO:0006813 potassium ion transport TAS
 biological_processGO:0007264 small GTPase mediated signal transduction TAS
 biological_processGO:0010923 negative regulation of phosphatase activity IDA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0017156 calcium ion regulated exocytosis IEA
 biological_processGO:0022406 membrane docking ISS
 biological_processGO:0030214 hyaluronan catabolic process TAS
 biological_processGO:0031122 cytoplasmic microtubule organization ISS
 biological_processGO:0031397 negative regulation of protein ubiquitination ISS
 biological_processGO:0031953 negative regulation of protein autophosphorylation ISS
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0032417 positive regulation of sodium:proton antiporter activity ISS
 biological_processGO:0042308 negative regulation of protein import into nucleus IDA
 biological_processGO:0050821 protein stabilization ISS
 biological_processGO:0051222 positive regulation of protein transport ISS
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0051453 regulation of intracellular pH IDA
 biological_processGO:0060050 positive regulation of protein glycosylation ISS
 biological_processGO:0061024 membrane organization ISS
 biological_processGO:0061025 membrane fusion ISS
 biological_processGO:0070885 negative regulation of calcineurin-NFAT signaling cascade IDA
 biological_processGO:0071468 cellular response to acidic pH ISS
 biological_processGO:0090314 positive regulation of protein targeting to membrane ISS
 biological_processGO:1901214 regulation of neuron death IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0015630 microtubule cytoskeleton ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030133 transport vesicle ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004860 protein kinase inhibitor activity IEA
 molecular_functionGO:0005215 transporter activity ISS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding ISS
 molecular_functionGO:0015459 potassium channel regulator activity TAS
 molecular_functionGO:0019900 kinase binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IDA


Pathways (from Reactome)
Pathway description
Hyaluronan uptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000026508 CD44 / P16070 / CD44 molecule (Indian blood group)  / complex / reaction
 ENSG00000133800 LYVE1 / Q9Y5Y7 / lymphatic vessel endothelial hyaluronan receptor 1  / complex / reaction
 ENSG00000090020 P19634 / SLC9A1 / solute carrier family 9 member A1  / complex
 ENSG00000072571 HMMR / O75330 / hyaluronan mediated motility receptor  / complex / reaction
 ENSG00000068001 HYAL2 / Q12891 / hyaluronoglucosaminidase 2  / complex / reaction
 ENSG00000136011 STAB2 / Q8WWQ8 / stabilin 2  / complex / reaction






 

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